Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling | |
Qu, Zhi Guo1,2; He, Xiao Cong1,2; Lin, Min2,3; Sha, Bao Yong2,4; Shi, Xing Hua5; Lu, Tian Jian2; Xu, Feng2,3 | |
刊名 | NANOMEDICINE |
2013-06-01 | |
通讯作者邮箱 | fengxu@mail.xjtu.edu.cn |
卷号 | 8期号:6页码:995-1011 |
关键词 | biomembrane interaction mathematical modeling nanomaterial numerical modeling |
ISSN号 | 1743-5889 |
通讯作者 | Xu, F (reprint author), Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China. |
产权排序 | [Qu, ZhiGuo; He, XiaoCong] Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermo Fluid Sci & Engn, Xian 710049, Peoples R China; [Qu, ZhiGuo; He, XiaoCong; Lin, Min; Sha, BaoYong; Lu, TianJian; Xu, Feng] Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China; [Lin, Min; Xu, Feng] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China; [Sha, BaoYong] Xian Med Univ, Lab Cell Biol & Translat Med, Xian 710021, Peoples R China; [Shi, XingHua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China |
合作状况 | 国内 |
中文摘要 | The widespread application of nanomaterials (NMs), which has accompanied advances in nanotechnology, has increased their chances of entering an organism, for example, via the respiratory system, skin absorption or intravenous injection. Although accumulating experimental evidence has indicated the important role of NM-biomembrane interaction in these processes, the underlying mechanisms remain unclear. Computational techniques, as an alternative to experimental efforts, are effective tools to simulate complicated biological behaviors. Computer simulations can investigate NM-biomembrane interactions at the nanoscale, providing fundamental insights into dynamic processes that are challenging to experimental observation. This paper reviews the current understanding of NM-biomembrane interactions, and existing mathematical and numerical modeling methods. We highlight the advantages and limitations of each method, and also discuss the future perspectives in this field. Better understanding of NM-biomembrane interactions can benefit various fields, including nanomedicine and diagnosis. |
英文摘要 | The widespread application of nanomaterials (NMs), which has accompanied advances in nanotechnology, has increased their chances of entering an organism, for example, via the respiratory system, skin absorption or intravenous injection. Although accumulating experimental evidence has indicated the important role of NM-biomembrane interaction in these processes, the underlying mechanisms remain unclear. Computational techniques, as an alternative to experimental efforts, are effective tools to simulate complicated biological behaviors. Computer simulations can investigate NM-biomembrane interactions at the nanoscale, providing fundamental insights into dynamic processes that are challenging to experimental observation. This paper reviews the current understanding of NM-biomembrane interactions, and existing mathematical and numerical modeling methods. We highlight the advantages and limitations of each method, and also discuss the future perspectives in this field. Better understanding of NM-biomembrane interactions can benefit various fields, including nanomedicine and diagnosis. |
学科主题 | 交叉与边缘领域的力学 |
分类号 | 二类/Q1 |
类目[WOS] | Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology |
研究领域[WOS] | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
关键词[WOS] | RECEPTOR-MEDIATED ENDOCYTOSIS ; MOLECULAR-DYNAMICS SIMULATION ; SUPPORTED LIPID-BILAYERS ; SUPERPARAMAGNETIC IRON-OXIDE ; INDUCED PORE FORMATION ; COARSE-GRAINED MODEL ; GOLD NANOPARTICLES ; CELLULAR UPTAKE ; COMPUTER-SIMULATION ; CARBON NANOTUBES |
收录类别 | SCI |
资助信息 | National Natural Science Foundation of China [10825210, 31050110125, 11272327]; National 111 Project of China [B06024]; China Young 1000-Talent Program; Shaanxi 100-Talent Program; Program for New Century Excellent Talents in University [NCET-12-0437]; International S&T Cooperation Program of China [2013DFG02930] |
原文出处 | http://dx.doi.org/10.2217/NNM.13.81 |
语种 | 英语 |
WOS记录号 | WOS:000319867000019 |
公开日期 | 2013-08-12 |
内容类型 | 期刊论文 |
源URL | [http://dspace.imech.ac.cn/handle/311007/47348] |
专题 | 力学研究所_非线性力学国家重点实验室 |
作者单位 | 1.Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermo Fluid Sci & Engn, Xian 710049, Peoples R China 2.Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China 3.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China 4.Xian Med Univ, Lab Cell Biol & Translat Med, Xian 710021, Peoples R China 5.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China |
推荐引用方式 GB/T 7714 | Qu, Zhi Guo,He, Xiao Cong,Lin, Min,et al. Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling[J]. NANOMEDICINE,2013,8(6):995-1011. |
APA | Qu, Zhi Guo.,He, Xiao Cong.,Lin, Min.,Sha, Bao Yong.,Shi, Xing Hua.,...&Xu, Feng.(2013).Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling.NANOMEDICINE,8(6),995-1011. |
MLA | Qu, Zhi Guo,et al."Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling".NANOMEDICINE 8.6(2013):995-1011. |
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