Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction
	Li, Shenghong1 ; Qiu, Shengxiang 2; Yao, Ping 3; Sun, Handong1 ; Fong, Harry H. S.4; Zhang, Hongjie 5
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2013
页码	432829
关键词	CONSTITUENTS FLAVONOIDS
ISSN号	1741-427X
通讯作者	Zhang, HJ (reprint author), Hong Kong Baptist Univ, Sch Chinese Med, 7 Baptist Univ Rd, Kowloon Tong, Hong Kong, Peoples R China. ; zhanghj@hkbu.edu.hk
英文摘要	As part of our continuing efforts in the search for potential biologically active compounds from medicinal plants, we have isolated 18 compounds including two novel nitrogen containing diterpenes from extracts of the fruits of Vitex agnus-castus. These isolates, along with our previously obtained novel compound vitexlactam A (1), were evaluated for potential biological effects, including cancer chemoprevention. Chemically, the nitrogenous isolates were found to be two labdane diterpene alkaloids, each containing an alpha,beta-unsaturated gamma-lactammoiety. Structurally, they were elucidated to be 9 alpha-hydroxy-13(14)-labden-16,15-amide (2) and 6 beta-acetoxy-9 alpha-hydroxy-13(14)-labden-15,16-amide (3), which were named vitexlactams B and C, respectively. The 15 known isolates were identified as vitexilactone (4), rotundifuran (5), 8-epi-manoyl oxide (6), vitetrifolin D (7), spathulenol (8), cis-dihydro-dehydro-diconiferylalcohol-9-O-beta-D-glucoside (9), luteolin-7-O-glucoside (10), 5-hydroxy-3,6,7,4'-tetramethoxyflavone (11), casticin (12), artemetin (13), aucubin (14), agnuside (15), beta-sitosterol (16), p-hydroxybenzoic acid (17), and p-hydroxybenzoic acid glucose ester (18). All compound structures were determined/identified on the basis of 1D and/or 2D NMR and mass spectrometry techniques. Compounds 6, 8, 9, and 18 were reported from a Vitex spieces for the first time. The cancer chemopreventive potentials of these isolates were evaluated for NADP(H): quinone oxidoreductase type 1 (QR1) induction activity. Compound 7 demonstrated promising QR1 induction effect, while the new compound vitexlactam (3) was only slightly active.
学科主题	Integrative & Complementary Medicine
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Integrative & Complementary Medicine
研究领域[WOS]	Integrative & Complementary Medicine
关键词[WOS]	CONSTITUENTS ; FLAVONOIDS
收录类别	SCI
资助信息	Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000317513200001
公开日期	2013-07-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16575]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 3.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China 4.Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA 5.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Li, Shenghong,Qiu, Shengxiang,Yao, Ping,et al. Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013:432829.
APA	Li, Shenghong,Qiu, Shengxiang,Yao, Ping,Sun, Handong,Fong, Harry H. S.,&Zhang, Hongjie.(2013).Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,432829.
MLA	Li, Shenghong,et al."Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013):432829.