Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis

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	Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis
	Wang, Hong-Ling 1,2; Cao, Tuan-Wu 1,2; Jiang, Fu-Qiang 1; Geng, Chang-An1 ; Zhang, Xue-Mei1 ; Huang, Xiao-Yan 1; Wang, Li-Jun 1; Kang-He, Sing Wd 1; Hao-Chen 1,2; Liang, Wen-Juan 1,2
刊名	TETRAHEDRON LETTERS
	2013-05-22
卷号	54 期号:21 页码:2710-2712
关键词	Swerpunilactones A-B Anti-HBV activity Swertia punicea Swertia hispidicalyx Swertia yunnanensis
ISSN号	0040-4039
通讯作者	Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; chenjj@mail.kib.ac.cn
英文摘要	Swerpunilactones A (1) and B (2), two novel xanthone and secoiridoid heterodimers, together with their presumed biosynthetic precursors (+/-)-gentiolactone (3), bellidifolin (4), and norbellidifolin (5), were isolated from the whole plants of Swertia species. A plausible biogenetic pathway for swerpunilactones A and B was proposed. In vitro anti-hepatitis B virus assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited activities against the secretion of HBsAg (IC50 = 0.25 and 0.29 mM), HBeAg (IC50 = 0.86 and 0.31 mM), and HBV DNA replication (IC50 = 0.18 and 0.19 mM). (c) 2013 Elsevier Ltd. All rights reserved.
学科主题	Chemistry
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	MILEENSIS
收录类别	SCI ; IC
资助信息	Natural National Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China and Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science [F/5202-1]
语种	英语
WOS记录号	WOS:000318393000037
公开日期	2013-06-08
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16455]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hong-Ling,Cao, Tuan-Wu,Jiang, Fu-Qiang,et al. Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis[J]. TETRAHEDRON LETTERS,2013,54(21):2710-2712.
APA	Wang, Hong-Ling.,Cao, Tuan-Wu.,Jiang, Fu-Qiang.,Geng, Chang-An.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2013).Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis.TETRAHEDRON LETTERS,54(21),2710-2712.
MLA	Wang, Hong-Ling,et al."Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis".TETRAHEDRON LETTERS 54.21(2013):2710-2712.