Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
	Wan, Qin-Li 1,2; Zheng, Shan-Qing 1,2; Wu, Gui-Sheng3,4 ; Luo, Huai-Rong1
刊名	EXPERIMENTAL GERONTOLOGY
	2013-05-01
卷号	48 期号:5 页码:499-506
关键词	Caenorhabditis elegans Aspirin Lifespan AMPK DAF-16/FOXO Dietary restriction
ISSN号	0531-5565
通讯作者	Luo, HR (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, 134 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China. ; luohuairong@mail.kib.ac.cn
英文摘要	Aspirin has been revealed to have many beneficial effects for health since it was discovered as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Here, we investigated the molecular mechanism of aspirin on the lifespan extension of Caenorhabditis elegans. Our results showed that aspirin could extend the lifespan of C. elegans, and increase its health span and stress resistance. The extension of lifespan by aspirin requires DAF-16/FOXO, AMPK, and LKB1, but not SIR-2.1. Aspirin could not extend the lifespan of the mutants of eat-2, clk-1, and isp-1. Aspirin could marginally extend the lifespan of long-live insulin-like receptor mutant daf-2(e1370) III. Taken together, aspirin might act through a dietary restriction-like mechanism, via increasing the AMP: ATP ratio and activating LKB1, subsequently activating AMPK, which stimulates DAF-16 to induce downstream effects through a DAF-16 translocation independent manner. (C) 2013 Elsevier Inc. All rights reserved.
学科主题	Geriatrics & Gerontology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Geriatrics & Gerontology
研究领域[WOS]	Geriatrics & Gerontology
关键词[WOS]	ACTIVATED PROTEIN-KINASE ; NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; C-ELEGANS ; CALORIE RESTRICTION ; GENETIC PATHWAYS ; OXIDATIVE STRESS ; LONGEVITY ; COLON ; METABOLISM ; DISEASE
收录类别	SCI
资助信息	Yunnan provincial government [20080A007]; Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P20080-ZZ21, T20090-KF05]
语种	英语
WOS记录号	WOS:000317182600007
公开日期	2013-06-08
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16451]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 4.Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,et al. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway[J]. EXPERIMENTAL GERONTOLOGY,2013,48(5):499-506.
APA	Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,&Luo, Huai-Rong.(2013).Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.EXPERIMENTAL GERONTOLOGY,48(5),499-506.
MLA	Wan, Qin-Li,et al."Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway".EXPERIMENTAL GERONTOLOGY 48.5(2013):499-506.