Core-crosslinked amphiphilic biodegradable copolymer based on the complementary multiple hydrogen bonds of nucleobases: synthesis, self-assembly and in vitro drug delivery

	Core-crosslinked amphiphilic biodegradable copolymer based on the complementary multiple hydrogen bonds of nucleobases: synthesis, self-assembly and in vitro drug delivery
	Kuang HH ; Wu SH ; Meng FB ; Xie ZG ; Jing XB ; Huang YB
刊名	journal of materials chemistry
	2012
卷号	22 期号:47 页码:24832-24840
关键词	BLOCK-COPOLYMERS POLYMERIC MICELLES KINETIC STABILITY LOADING CAPACITY DOXORUBICIN DESIGN FUNCTIONALIZATION NANOSTRUCTURES CHEMISTRY
ISSN号	0959-9428
通讯作者	meng fb
中文摘要	nucleobases (adenine and thymine) were conjugated to the amphiphilic biodegradable copolymers methoxyl poly(ethylene glycol)-b-poly(l-lactide-co-2-methyl-2-allyloxycarbonylpropylene carbonate) (mpeg-b-p(la-co-mac)). the hydrogen bonds between adenine (a) and thymine (t) were confirmed by h-1 nmr titration experiments and ft-ir. it was found that the incorporation of nucleobases into the hydrophobic segment of the amphiphilic copolymers could be used for core-crosslinking of the formed micelles containing a lowered critical micelle concentration (cmc) via hydrogen bond interaction between a and t in aqueous solution. the anticancer drug doxorubicin (dox) was encapsulated into the copolymer micelles. the in vitro drug release profile showed that the incorporation of nucleobases significantly restricted dox release at ph 7.4, because of the compact crosslinking structure of micelles. however, a much faster release rate was observed at ph 5.0, due to the dissociation of hydrogen bonds between nucleobases. this character facilitates drug delivery in the acidic tumor micro-environment inside the endosome. meanwhile, the dox-loaded core-cross-linked micelles could be efficiently internalized into cancer cells and exhibit similar anticancer efficacy as free dox against mda-mb-231 cells. therefore, the complementary multiple hydrogen bonds of nucleobases provided a convenient tool to stabilize the micelle structures by forming core-crosslinking, and could be further applied for controlled drug delivery.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000311808200044
公开日期	2013-06-09
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48417]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Kuang HH,Wu SH,Meng FB,et al. Core-crosslinked amphiphilic biodegradable copolymer based on the complementary multiple hydrogen bonds of nucleobases: synthesis, self-assembly and in vitro drug delivery[J]. journal of materials chemistry,2012,22(47):24832-24840.
APA	Kuang HH,Wu SH,Meng FB,Xie ZG,Jing XB,&Huang YB.(2012).Core-crosslinked amphiphilic biodegradable copolymer based on the complementary multiple hydrogen bonds of nucleobases: synthesis, self-assembly and in vitro drug delivery.journal of materials chemistry,22(47),24832-24840.
MLA	Kuang HH,et al."Core-crosslinked amphiphilic biodegradable copolymer based on the complementary multiple hydrogen bonds of nucleobases: synthesis, self-assembly and in vitro drug delivery".journal of materials chemistry 22.47(2012):24832-24840.