Roles of intracellular fibroblast growth factors in neural development and functions

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	Roles of intracellular fibroblast growth factors in neural development and functions
	Zhang, X
刊名	SCIENCE CHINA-LIFE SCIENCES
	2012
卷号	55 期号:12 页码:1038-1044
关键词	FACTOR HOMOLOGOUS FACTORS GATED SODIUM-CHANNELS MICE LACKING FIBROBLAST-GROWTH-FACTOR-14 LINKED MENTAL-RETARDATION DORSAL-ROOT GANGLION FOLLISTATIN-LIKE 1 NEURONAL MIGRATION NEUROPATHIC PAIN FACTOR FAMILY INTELLECTUAL DISABILITY
ISSN号	1674-7305
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
英文摘要	Fibroblast growth factors (FGFs) can be classified as secretory (FGF1-10 and FGF15-23) or intracellular non-secretory forms (FGF11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be explored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neurons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A recent study showed that FGF13 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases.
学科主题	Life Sciences & Biomedicine - Other Topics
收录类别	SCI
资助信息	National Natural Science Foundation of China [31130066, 30630029]; National Basic Research Program of China [2011CBA00400, 2009CB522005]; Strategic Priority Research Program (B) of Chinese Academy of Sciences [XDB02010200]
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2500]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhang, X. Roles of intracellular fibroblast growth factors in neural development and functions[J]. SCIENCE CHINA-LIFE SCIENCES,2012,55(12):1038-1044.
APA	Zhang, X.(2012).Roles of intracellular fibroblast growth factors in neural development and functions.SCIENCE CHINA-LIFE SCIENCES,55(12),1038-1044.
MLA	Zhang, X."Roles of intracellular fibroblast growth factors in neural development and functions".SCIENCE CHINA-LIFE SCIENCES 55.12(2012):1038-1044.