Activity-Induced Long-Term Potentiation of Excitatory Synapses in Developing Zebrafish Retina In Vivo

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	Activity-Induced Long-Term Potentiation of Excitatory Synapses in Developing Zebrafish Retina In Vivo
	Du, JL
刊名	NEURON
	2012
卷号	75 期号:3 页码:479-489
关键词	GANGLION-CELL DENDRITES MEDIATED AFFERENT ACTIVITY ARACHIDONIC-ACID SYNAPTIC PLASTICITY BIPOLAR CELLS DEPENDENT PLASTICITY VISUAL DEPRIVATION MAMMALIAN RETINA RELEASE SYSTEM
ISSN号	0896-6273
通讯作者	Du, JL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn
英文摘要	Neural activity-induced long-term potentiation (LTP) of synaptic transmission is believed to be one of the cellular mechanisms underlying experience-dependent developmental refinement of neural circuits. Although it is well established that visual experience and neural activity are critical for the refinement of retinal circuits, whether and how LTP occurs in the retina remain unknown. Using in vivo perforated whole-cell recording and two-photon calcium imaging, we find that both repeated electrical and visual stimulations can induce LTP at excitatory synapses formed by bipolar cells on retinal ganglion cells in larval but not juvenile zebrafish. LTP induction requires the activation of postsynaptic N-methyl-D-aspartate receptors, and its expression involves arachidonic acid-dependent presynaptic changes in calcium dynamics and neurotransmitter release. Physiologically, both electrical and visual stimulation-induced LIP can enhance visual responses of retinal ganglion cells. Thus, LIP exists in developing retinae with a presynaptic locus and may serve for visual experience-dependent refinement of retinal circuits.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Basic Research Program of China [2011CBA00400, 2012CB945101, 2006CB943802]; Shanghai government [06dj14010, 07pj14107]; Hundred Talents Program from Chinese Academy of Sciences
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2475]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Du, JL. Activity-Induced Long-Term Potentiation of Excitatory Synapses in Developing Zebrafish Retina In Vivo[J]. NEURON,2012,75(3):479-489.
APA	Du, JL.(2012).Activity-Induced Long-Term Potentiation of Excitatory Synapses in Developing Zebrafish Retina In Vivo.NEURON,75(3),479-489.
MLA	Du, JL."Activity-Induced Long-Term Potentiation of Excitatory Synapses in Developing Zebrafish Retina In Vivo".NEURON 75.3(2012):479-489.