Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats

	Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats
	Liu DX ; Liu S ; Jing XB ; Li XY ; Li WL ; Huang YB
刊名	biomaterials
	2012
卷号	33 期号:17 页码:4362-4369
关键词	CANCER-CELL METABOLISM ATP DEPLETION IN-VITRO APOPTOSIS DRUG GROWTH DCA GLYCOLYSIS SURVIVAL THERAPY
ISSN号	0142-9612
通讯作者	huang yb
中文摘要	it is still a great challenge to apply therapeutic concentration of anti-cancer drugs to the tumor site with low system toxicity. an in situ administration strategy was applied to reverse the aerobic glycolysis of tumor in vivo for the first time. controlled release of therapeutic concentration of dichloroacetate (dca) from polylactide (pla) electrospun mats covering the solid tumor locally was designed to suppress the cervical carcinoma in vivo. a dramatic decrease in the volume and weight of tumors was observed for 19 days in tumor-bearing mice, and a totally 96% of the tumor suppression degree was obtained even the initial tumor volume was around 200 mm(3). half of the mice recovered in less than 3 weeks. necrosis was examined rather than apoptosis on the tumor cells as the main process of cell death induced by the dca-loaded electrospun mats. a proposed necroptosis mechanism was presented to explain the signal pathways that were induced by the metabolic remodeling of dca. it provided support for this strategy that target the bio-energy metabolism of the cervical carcinoma locally is a quick and effective pathway to cure the advanced-carcinoma of cervical. (c) 2012 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000303181500013
公开日期	2013-05-20
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48131]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu DX,Liu S,Jing XB,et al. Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats[J]. biomaterials,2012,33(17):4362-4369.
APA	Liu DX,Liu S,Jing XB,Li XY,Li WL,&Huang YB.(2012).Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats.biomaterials,33(17),4362-4369.
MLA	Liu DX,et al."Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats".biomaterials 33.17(2012):4362-4369.