Simultaneous determination of three beta-blockers at a carbon nanofiber paste electrode by capillary electrophoresis coupled with amperometric detection

	Simultaneous determination of three beta-blockers at a carbon nanofiber paste electrode by capillary electrophoresis coupled with amperometric detection
	Xu L ; Guo QH ; Yu H ; Huang JS ; You TY
刊名	talanta
	2012
卷号	97 页码:462-467
关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY HUMAN URINE ELECTROCHEMICAL DETECTION FLUORESCENCE DETECTION ZONE-ELECTROPHORESIS SENSITIVE DETECTION ATENOLOL METABOLITES NADH
ISSN号	0039-9140
通讯作者	you ty
中文摘要	in the paper, a novel carbon nanofiber paste electrode (cfpe) was fabricated and firstly used as a sensitive amperometric detector in capillary electrophoresis (ce) for the simultaneous determination of three beta-blockers: sotalol, alprenolol and atenolol. compared with the bare carbon paste electrode, the cfpe exhibited enhanced oxidation peak current responses to the analytes due to its excellent electrocatalytic activities, high conductivity and large effective surface area. subsequently, effects of several important factors such as detection potential, ph and concentration of running buffer, separation voltage and injection time on the analysis were investigated. under the optimum conditions, the three analytes could be separated and detected in a phosphate buffer (ph 8.5) within 11 min. the linear ranges were 0.1-100 mu m for sotalol, 0.2-150 mu m for alprenolol and 0.1-50 mu m for atenolol and the detection limits were as low as 10(-8) m magnitude (s/n=3). moreover, the cfpe exhibited good repeatability and long-time stability. the proposed method was applied to determine the three beta-blockers in spiked urine samples with satisfactory assay results. the good performance, low cost and straightforward preparation method of cfpe demonstrated that it could be used as a detector for ce-amperometric detection system for drug analysis. crown copyright (c) 2012 published by elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000308268800070
公开日期	2013-04-23
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47999]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xu L,Guo QH,Yu H,et al. Simultaneous determination of three beta-blockers at a carbon nanofiber paste electrode by capillary electrophoresis coupled with amperometric detection[J]. talanta,2012,97:462-467.
APA	Xu L,Guo QH,Yu H,Huang JS,&You TY.(2012).Simultaneous determination of three beta-blockers at a carbon nanofiber paste electrode by capillary electrophoresis coupled with amperometric detection.talanta,97,462-467.
MLA	Xu L,et al."Simultaneous determination of three beta-blockers at a carbon nanofiber paste electrode by capillary electrophoresis coupled with amperometric detection".talanta 97(2012):462-467.