A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance

	A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance
	Xiao HH ; Song HQ ; Yang Q ; Cai HD ; Qi RG ; Yan LS ; Liu S ; Zheng YH ; Huang YB ; Liu TJ ; Jing XB
刊名	biomaterials
	2012
卷号	33 期号:27 页码:6507-6519
关键词	COMBINATION CHEMOTHERAPY BIODEGRADABLE POLYMER BREAST-CANCER THERAPY DRUG REDUCTION RECURRENT TAXOL ACID
ISSN号	0142-9612
通讯作者	jing xb
中文摘要	a strategy of preparing composite micelles containing both cisplatin(iv) prodrug and paclitaxel was developed, i.e., synthesizing a cisplatin(iv) conjugate and a paclitaxel conjugate starting with the same biodegradable and amphiphilic block copolymer, and co-assembling the two conjugates. the composite micelles could release effective anticancer drug cisplatin(ii) upon cellular reduction and ptx via acid hydrolysis once they came into the cancerous cells. moreover, the composite micelles displayed synergistic effect in vitro and the combination therapy in micellar dosage-form led to reduced systematic toxicity and enhanced antitumor efficacy in vivo. (c) 2012 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000307148200021
公开日期	2013-04-23
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47980]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xiao HH,Song HQ,Yang Q,et al. A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance[J]. biomaterials,2012,33(27):6507-6519.
APA	Xiao HH.,Song HQ.,Yang Q.,Cai HD.,Qi RG.,...&Jing XB.(2012).A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance.biomaterials,33(27),6507-6519.
MLA	Xiao HH,et al."A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance".biomaterials 33.27(2012):6507-6519.