Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers

	Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers
	Song WT ; Li MQ ; Tang ZH ; Li QS ; Yang Y ; Liu HY ; Duan TC ; Hong H ; Chen XS
刊名	macromolecular bioscience
	2012
卷号	12 期号:11 页码:1514-1523
关键词	DRUG-DELIVERY IN-VIVO PLATINUM COMPLEXES POLYMERIC MICELLES ANTITUMOR-ACTIVITY TARGETED DELIVERY BLOCK-COPOLYMER NANOPARTICLES PACLITAXEL THERAPY
ISSN号	1616-5187
通讯作者	hong h
中文摘要	cddp is loaded into methoxypoly(ethylene glycol)-block-poly(l-glutamic acid) (mpeg-b-plg), and a combination with irgd is applied for nsclc chemotherapy. the cddp-loaded micelles show sustained cisplatin release in pbs, dose- and time-dependent inhibition to hela and a549 cell proliferation, and no apparent hemolysis activities. in in vivo studies using subcutaneous nsclc xenograft models (a549), both free cddp and cddp-loaded micelles show an evident anti-tumor effect. however, the toxicity of cddp is significantly reduced in the cases of cddp-loaded micelles and co-administration with irgd, and the survival time is prolonged by over 30%. therefore, mpeg-b-plg-loaded cisplatin and the combination with irgd provides a promising new therapy for nsclc.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000310601500009
公开日期	2013-04-22
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47876]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Song WT,Li MQ,Tang ZH,et al. Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers[J]. macromolecular bioscience,2012,12(11):1514-1523.
APA	Song WT.,Li MQ.,Tang ZH.,Li QS.,Yang Y.,...&Chen XS.(2012).Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers.macromolecular bioscience,12(11),1514-1523.
MLA	Song WT,et al."Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers".macromolecular bioscience 12.11(2012):1514-1523.