Metallosupramolecular complex targeting an alpha/beta discordant stretch of amyloid beta peptide

	Metallosupramolecular complex targeting an alpha/beta discordant stretch of amyloid beta peptide
	Yu HJ ; Li M ; Liu, GP ; Geng J ; Wang JZ ; Ren JS ; Zhao CQ ; Qu XG
刊名	chemical science
	2012
卷号	3 期号:11 页码:3145-3153
关键词	LONG-TERM POTENTIATION ALZHEIMERS-DISEASE FIBRIL FORMATION MOUSE MODEL A-BETA IN-VITRO CYCLIN A(2) AGGREGATION INHIBITORS OLIGOMERS
ISSN号	2041-6520
通讯作者	qu xg
中文摘要	the accumulation of amyloid beta-peptide (a beta) is one of the pathological hallmarks of alzheimer's disease (ad). developing a beta amyloid inhibitors has received much attention. most reported a beta inhibitors are small organic molecules or peptides. here we use a cell-based novel a beta-enhanced cyan fluorescent protein (ecfp) fluorescent fusion inhibitor screen system, biochemical and biophysical approaches and in vivo studies to identify two zinc-finger-like triple-helical metallo-supramolecular cylinders, [ni2l3](4+) and [fe2l3](4+), that can strongly inhibit alzheimer's disease beta-amyloid aggregation. further studies indicate that the two metallo-supramolecular cylinders are specifically targeting the alpha/beta-discordant stretch and reducing a beta cytotoxicity. in vivo studies demonstrate that these complexes can ameliorate spatial memory deficits in a transgenic mouse model and decrease the insoluble a beta level. this is the first demonstration that zinc-finger-like metallo-supramolecular cylinders can be a beta aggregation inhibitors that specifically target an alpha/beta-discordant stretch. our work will prompt design and screening of metallo-supramolecular complexes as potential therapeutic agents for ad.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000311068100002
公开日期	2013-04-22
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47872]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Yu HJ,Li M,Liu, GP,et al. Metallosupramolecular complex targeting an alpha/beta discordant stretch of amyloid beta peptide[J]. chemical science,2012,3(11):3145-3153.
APA	Yu HJ.,Li M.,Liu, GP.,Geng J.,Wang JZ.,...&Qu XG.(2012).Metallosupramolecular complex targeting an alpha/beta discordant stretch of amyloid beta peptide.chemical science,3(11),3145-3153.
MLA	Yu HJ,et al."Metallosupramolecular complex targeting an alpha/beta discordant stretch of amyloid beta peptide".chemical science 3.11(2012):3145-3153.