Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels

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	Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels
	Sun JS; Liu C(刘超); Li MM; Wang JD; Xianyu YL; Hu GQ(胡国庆); Jiang XY
刊名	BIOMICROFLUIDICS
	2013-02-04
通讯作者邮箱	guoqing.hu@imech.ac.cn; xingyujiang@nanoctr.cn
卷号	7 期号:1 页码:011802/1-011802/11
关键词	bioMEMS cellular biophysics hydrodynamics microchannel flow tumours
ISSN号	1932-1058
通讯作者	Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.
产权排序	[Sun, Jiashu; Li, Mengmeng; Wang, Jidong; Xianyu, Yunlei; Jiang, Xingyu] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liu, Chao; Hu, Guoqing] Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China
合作状况	国内
中文摘要	In this work, we propose a rapid and continuous rare tumor cell separation based on hydrodynamic effects in a label-free manner. The competition between the inertial lift force and Dean drag force inside a double spiral microchannel results in the size-based cell separation of large tumor cells and small blood cells. The mechanism of hydrodynamic separation in curved microchannel was investigated by a numerical model. Experiments with binary mixture of 5- and 15-mu m-diameter polystyrene particles using the double spiral channel showed a separation purity of more than 95% at the flow rate above 30 ml/h. High throughput (2.5 x 10(8) cells/min) and efficient cell separation (more than 90%) of spiked HeLa cells and 20 x diluted blood cells was also achieved by the double spiral channel.
学科主题	微机电系统中的流体力学问题
分类号	一类
收录类别	SCI ; EI
资助信息	MOST [2011CB933201, 2009CB930001, 2011CB707604]; NSFC [51105086, 21025520, 90813032, 50890182]; CAS [KJCX2-YW-M15, KJCX2-YW-H18]
原文出处	http://dx.doi.org/10.1063/1.4774311
语种	英语
WOS记录号	WOS:000315597100008
公开日期	2013-04-01
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/47122]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Sun JS,Liu C,Li MM,et al. Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels[J]. BIOMICROFLUIDICS,2013,7(1):011802/1-011802/11.
APA	Sun JS.,刘超.,Li MM.,Wang JD.,Xianyu YL.,...&Jiang XY.(2013).Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels.BIOMICROFLUIDICS,7(1),011802/1-011802/11.
MLA	Sun JS,et al."Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels".BIOMICROFLUIDICS 7.1(2013):011802/1-011802/11.