Single Molecular Recognition Force Spectroscopy Study of a Luteinizing Hormone-Releasing Hormone Analogue as a Carcinoma Target Drug

	Single Molecular Recognition Force Spectroscopy Study of a Luteinizing Hormone-Releasing Hormone Analogue as a Carcinoma Target Drug
	Zhang J ; Wu GM ; Song CL ; Li YJ ; Qiao HY ; Zhu P ; Hinterdorfer P ; Zhang BL ; Tang JL
刊名	journal of physical chemistry b
	2012
卷号	116 期号:45 页码:13331-13337
关键词	IMMUNOTOXIN RFB4(DSFV)-PE38 BL22 LIVING CELLS MICROSCOPY RECEPTOR MALIGNANCIES PEPTIDE BINDING SYSTEM TOXINS BONDS
ISSN号	1520-6106
通讯作者	zhang bl
中文摘要	the luteinizing hormone-releasing hormone-pseudomonas aeruginosa exotoxin 40 (lhrh-pe40), is a candidate target drug associated with elevated lhrh receptor (lhrh-r) expression in malignant tumor tissue. the capability of lhrh-pe40 to recognize lhrh-rs on a living cell membrane was studied with single molecular recognition force spectroscopy (smfs) based on atomic force microscopy (afm). the recognition force of lhrh-pe40/lhrh-r was compared with that of lhrh/lhrh-r by dynamic force spectroscopy. meanwhile, cell growth inhibition assay and fluorescence imaging were presented as complementary. characterization. the results show that lhrh moiety keeps its capability to recognize lhrh-r specifically, which implies, that recombinant protein,lhrh-pe40 can be a promising target drug.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000311192000004
公开日期	2013-03-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47832]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang J,Wu GM,Song CL,et al. Single Molecular Recognition Force Spectroscopy Study of a Luteinizing Hormone-Releasing Hormone Analogue as a Carcinoma Target Drug[J]. journal of physical chemistry b,2012,116(45):13331-13337.
APA	Zhang J.,Wu GM.,Song CL.,Li YJ.,Qiao HY.,...&Tang JL.(2012).Single Molecular Recognition Force Spectroscopy Study of a Luteinizing Hormone-Releasing Hormone Analogue as a Carcinoma Target Drug.journal of physical chemistry b,116(45),13331-13337.
MLA	Zhang J,et al."Single Molecular Recognition Force Spectroscopy Study of a Luteinizing Hormone-Releasing Hormone Analogue as a Carcinoma Target Drug".journal of physical chemistry b 116.45(2012):13331-13337.