Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery

	Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery
	Kang XJ ; Dai YL ; Ma PA ; Yang DM ; Li CX ; Hou ZY ; Cheng ZY ; Lin J
刊名	chemistry-a european journal
	2012
卷号	18 期号:49 页码:15676-15682
关键词	SUSTAINED-RELEASE PROPERTY MESOPOROUS SPHERES SILICA SPHERES CANCER-THERAPY NANOPARTICLES CARRIERS LUMINESCENT NANOCRYSTALS CONTAINERS SYSTEM
ISSN号	0947-6539
通讯作者	cheng zy
中文摘要	monodisperse poly(acrylic acid)-modified fe3o4 (paa@fe3o4) hybrid microspheres with dual responses (magnetic field and ph) were successfully fabricated. the paa polymer was encapsulated into the inner cavity of fe3o4 hollow spheres by a vacuum-casting route and photo-initiated polymerization. tem images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. the fe3o4 spheres, after modification with the paa polymer, still possess enough space to hold guest molecules. we selected doxorubicin (dox) as a model drug to investigate the drug loading and release behavior of as-prepared composites. the release of dox molecules was strongly dependent on the ph value due to the unique property of paa. the hela cell-uptake process of dox-loaded paa@fe3o4 was observed by confocal laser scanning microscopy (clsm). after being incubated with hela cells under magnet magnetically guided conditions, the cytotoxtic effects of dox-loaded paa@fe3o4 increased. these results indicate that ph-responsive magnetic paa@fe3o4 spheres have the potential to be used as anticancer drug carriers.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000311438200015
公开日期	2013-03-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47814]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Kang XJ,Dai YL,Ma PA,et al. Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery[J]. chemistry-a european journal,2012,18(49):15676-15682.
APA	Kang XJ.,Dai YL.,Ma PA.,Yang DM.,Li CX.,...&Lin J.(2012).Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery.chemistry-a european journal,18(49),15676-15682.
MLA	Kang XJ,et al."Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery".chemistry-a european journal 18.49(2012):15676-15682.