C-F Bond Cleavage by Intramolecular S(N)2 Reaction of Alkyl Fluorides with O- and N-Nucleophiles

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	C-F Bond Cleavage by Intramolecular S(N)2 Reaction of Alkyl Fluorides with O- and N-Nucleophiles
	Zhang LJ(张来俊) ; Zhang W(张伟) ; Liu J(刘俊) ; Hu JB(胡金波)
刊名	J. Org. Chem.
	2009
卷号	74 期号:7 页码:2850-2853
ISSN号	0022-3263
其他题名	利用氧-和氮-亲核试剂对烷基氟化物的SN2反应来实现C-F键断裂
通讯作者	胡金波
英文摘要	The nucleophilic substitution of alkyl fluorides was achieved in the intramolecular reactions with O- and N-nucleophiles. The intramolecular defluorinative cyclization reaction was influenced by the nature of nucleophiles, the size of the ring to be formed, and the comformational rigidity of the precursors. Intermolecular nucleophilic substitution reactions of alkyl fluorides under similar reaction conditions were found to be difficult. The stereochemistry study of the current C-F bond cleavage reaction showed a complete configurational inversion, which supports an intramolecular S(N)2 reaction mechanism.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/jo802819p
语种	英语
WOS记录号	WOS:000264627400030
公开日期	2013-03-11
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/24049]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式 GB/T 7714	Zhang LJ,Zhang W,Liu J,et al. C-F Bond Cleavage by Intramolecular S(N)2 Reaction of Alkyl Fluorides with O- and N-Nucleophiles[J]. J. Org. Chem.,2009,74(7):2850-2853.
APA	张来俊,张伟,刘俊,&胡金波.(2009).C-F Bond Cleavage by Intramolecular S(N)2 Reaction of Alkyl Fluorides with O- and N-Nucleophiles.J. Org. Chem.,74(7),2850-2853.
MLA	张来俊,et al."C-F Bond Cleavage by Intramolecular S(N)2 Reaction of Alkyl Fluorides with O- and N-Nucleophiles".J. Org. Chem. 74.7(2009):2850-2853.