Pushing radical cyclization from regioselective to regiospecific: Cyclization of amidyl radicals controlled by vinylic halogen substitution

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	Pushing radical cyclization from regioselective to regiospecific: Cyclization of amidyl radicals controlled by vinylic halogen substitution
	Hu TS(胡天顺) ; Shen MH(沈美华) ; Chen Q(陈迁) ; Li CZ(李超忠)
刊名	Org. Lett.
	2006
卷号	8 期号:12 页码:2647-2650
ISSN号	1523-7060
其他题名	促使自由基环合由区域选择走向区域专一：烯基卤素取代控制的酰胺氮自由基环合反应
通讯作者	李超忠
英文摘要	Efficient and regiospecific 6-exo, 7-endo, 7-exo, and even 8-endo amidyl radical cyclizations can be accomplished by the direct reactions of unsaturated N-H amides if they bear a vinylic halogen (Cl, Br, I) substituent. This remarkable halogen-substitution effect could be rationalized in terms of lone pair-lone pair electron repulsion between the N radical and the vinylic halogen atom, in addition to the well-known steric and radical-stabilizing effect.
学科主题	有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ol060983q
语种	英语
WOS记录号	WOS:000237951800051
公开日期	2013-03-04
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/22816]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Hu TS,Shen MH,Chen Q,et al. Pushing radical cyclization from regioselective to regiospecific: Cyclization of amidyl radicals controlled by vinylic halogen substitution[J]. Org. Lett.,2006,8(12):2647-2650.
APA	胡天顺,沈美华,陈迁,&李超忠.(2006).Pushing radical cyclization from regioselective to regiospecific: Cyclization of amidyl radicals controlled by vinylic halogen substitution.Org. Lett.,8(12),2647-2650.
MLA	胡天顺,et al."Pushing radical cyclization from regioselective to regiospecific: Cyclization of amidyl radicals controlled by vinylic halogen substitution".Org. Lett. 8.12(2006):2647-2650.