Bidirectional synthesis of the central amino acid of chloptosin

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	Bidirectional synthesis of the central amino acid of chloptosin
	Hong WX(洪文旭) ; Chen LJ(陈玲君) ; Zhong CL(仲春龙) ; Yao ZJ(姚祝军)
刊名	Org. Lett.
	2006
卷号	8 期号:21 页码:4919-4922
ISSN号	1523-7060
其他题名	Chloptosin主要核心氨基酸的双向合成
通讯作者	姚祝军
英文摘要	An efficient total synthesis of (2S,2'S,3aR,3'aR,8aR,8a R)-6,6'-dichloro-3a,3'a-dihydroxy-1,1',2,2', 3,3a,3',3'a,8,8a,8',8'a-dodecahydro-5,5'-bipyrrol[2,3-b]indole-2,2'-dica rboxylic acid, the central amino acid component of chloptosin (1), is described. Starting from m-chloronitrobenzene, this C-2-symmetrical amino acid was synthesized by using a 14-step route, in which a Zinin benzidine rearrangement, intramolecular Heck reaction, and selenocyclization and oxidative deselenation served as key steps. The absolute stereochemistry of the target was confirmed by X-ray single-crystal studies on a key intermediate (17).
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ol0620139
语种	英语
WOS记录号	WOS:000241030900063
公开日期	2013-02-26
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/21075]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Hong WX,Chen LJ,Zhong CL,et al. Bidirectional synthesis of the central amino acid of chloptosin[J]. Org. Lett.,2006,8(21):4919-4922.
APA	洪文旭,陈玲君,仲春龙,&姚祝军.(2006).Bidirectional synthesis of the central amino acid of chloptosin.Org. Lett.,8(21),4919-4922.
MLA	洪文旭,et al."Bidirectional synthesis of the central amino acid of chloptosin".Org. Lett. 8.21(2006):4919-4922.