Difluoromethylenated Polyhydroxylated Pyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation

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	Difluoromethylenated Polyhydroxylated Pyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation
	Wang RW(王若文) ; Xu J(徐军) ; Oscar Lopez ; Mikael Bols ; Qing FL(卿凤翎)
刊名	Future Med. Chem.
	2009
卷号	1 期号:5 页码:991-997
ISSN号	1756-8919
其他题名	含二氟亚甲基多羟基吡咯: 合成、晶体结构和生物活性
通讯作者	卿凤翎
英文摘要	In our ongoing program aimed atthe design, synthesis and biological evaluation of novel gem-difluoromethylenated glycosidase inhibitors, the gem-difluoromethylenated polyhydroxylated pyrrolidines as analogues of 2.5-dideoxy-2.5-imino-D-mannitol (DMDP) were designed and prepared. The crystal structure of gem-difluoromethylenated polyhydroxylated pyrrolidine 17 contains an N-H...F intermolecular hydrogen bond. The biological assessment of gem-difluoromethylenated polyhydroxylated pymlidines showed that the modification by the gem-difluoromethylene group decreased the inhibitory activities of DMDP.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.4155/fmc.09.82
语种	英语
WOS记录号	WOS:000276093600020
公开日期	2013-02-22
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/17663]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式 GB/T 7714	Wang RW,Xu J,Oscar Lopez,et al. Difluoromethylenated Polyhydroxylated Pyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation[J]. Future Med. Chem.,2009,1(5):991-997.
APA	王若文,徐军,Oscar Lopez,Mikael Bols,&卿凤翎.(2009).Difluoromethylenated Polyhydroxylated Pyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation.Future Med. Chem.,1(5),991-997.
MLA	王若文,et al."Difluoromethylenated Polyhydroxylated Pyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation".Future Med. Chem. 1.5(2009):991-997.