Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography

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	Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography
	Wu Hankui; Su Zhen; Yang Yi; Ba Hang; Aisa Haji Akber
刊名	Journal of Chromatography A
	2007
卷号	1176 期号:40910 页码:217-222
关键词	Cichorium glandulosum HSCCC lactucopicrin 11 beta 13-dihydrolactucin lactucin
ISSN号	219673
通讯作者	Aisa, HA
英文摘要	Because of the skeletal complexity and similarity of the polarity, little research was reported on the isolation of sesquiterpene lactones by high-speed counter-current chromatography (HSCCC). Herein, three sesquiterpene lactones were successfully purified from the ethyl acetate extract of the roots of the traditional Uyghur medicinal plant Cichorium glandulosum Boiss. et Huet. by HSCCC. The separation was performed in two steps with two solvent systems: n-hexane-ethyl acetate-methanol-water (1.5:5:2.75:5, v/v/v/v) and ethyl acetate-methanol-water (20:1:20, v/v/v). From 166 mg of the ethyl acetate extract, 19 mg of lactucopicrin was isolated with the first solvent system and 10 mg of 11β,13-dihydrolactucin and 16 mg of lactucin were obtained with the second solvent system. All purified compounds were over 94% purity as determined by HPLC analysis, and these chemical structures were confirmed by ¹H NMR and ¹³C NMR.
收录类别	SCI
WOS记录号	WOS:000251848100026
公开日期	2012-11-29
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/2080]
专题	新疆理化技术研究所_资源化学研究室
作者单位	Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wu Hankui,Su Zhen,Yang Yi,et al. Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography[J]. Journal of Chromatography A,2007,1176(40910):217-222.
APA	Wu Hankui,Su Zhen,Yang Yi,Ba Hang,&Aisa Haji Akber.(2007).Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography.Journal of Chromatography A,1176(40910),217-222.
MLA	Wu Hankui,et al."Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography".Journal of Chromatography A 1176.40910(2007):217-222.