Preparation and characterization of chitosan-casein phosphopeptides biocomposite coatings on the medical titanium alloy

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 固体润滑国家重点实验室

	Preparation and characterization of chitosan-casein phosphopeptides biocomposite coatings on the medical titanium alloy
	Yang SR(杨生荣); Wang JQ(王金清)
刊名	Key Engineering Materials
	2011
卷号	480-481 页码:1065-1069
关键词	Titanium alloy Chitosan Casein phosphopeptides Composite coatings
ISSN号	1662-9795
通讯作者	刘斌
中文摘要	Titanium (Ti) and its alloys have been applied in orthopedics as one of the most popular biomedical metallic implant materials. In this work, to enhance the bioactivity, the surface of Ti alloy pre-modified by silane coupling agent and glutaraldehyde was covalently grafted with chitosan (CS) via biochemical multistep self-assembled method. Then, for the first time, the achieved surface was further immobilized with casein phosphopeptides (CPP), which are one group of bioactive peptides released from caseins in the digestive tract and can facilitate the calcium adsorption and usage, to form CS-CPP biocomposite coatings. The structure and composition of the fabricated coatings were characterized by X-ray photoelectron spectroscopy (XPS), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and atomic force microscopy (AFM). As the experimental results indicated, multi-step assembly was successfully performed, and the CS and CPP were assembled onto the Ti alloy surface orderly. It is anticipated that the Ti alloys modified by CS-CPP biocomposite coatings will find potential applications as implant materials in biomedical fields.
学科主题	材料科学与物理化学
收录类别	SCI
资助信息	the National Natural Science Foundation of China (Grant NO.50801065);“Top Hundred Talents Program” of Chinese Academy of Sciences
语种	英语
公开日期	2012-09-24
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/776]
专题	兰州化学物理研究所_固体润滑国家重点实验室
推荐引用方式 GB/T 7714	Yang SR,Wang JQ. Preparation and characterization of chitosan-casein phosphopeptides biocomposite coatings on the medical titanium alloy[J]. Key Engineering Materials,2011,480-481:1065-1069.
APA	杨生荣,&王金清.(2011).Preparation and characterization of chitosan-casein phosphopeptides biocomposite coatings on the medical titanium alloy.Key Engineering Materials,480-481,1065-1069.
MLA	杨生荣,et al."Preparation and characterization of chitosan-casein phosphopeptides biocomposite coatings on the medical titanium alloy".Key Engineering Materials 480-481(2011):1065-1069.