Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity

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	Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity
	Xu LW(徐利文) ; Ju YD(鞠亚东) ; Li L(李莉) ; Qiu HY(邱化玉) ; Jiang JX(蒋剑雄) ; Lai GQ(来国桥)
刊名	Tetrahedron Letters
	2008
卷号	49 页码:7037-7041
关键词	Enamine catalysis Primary amine Aldol reaction Polysiloxane Organocatalysis
ISSN号	0040-4039
通讯作者	徐利文 ; 来国桥
中文摘要	We have developed a new strategy to improve the stereoselectivity in enamine catalysis by the introduction of super-hydrophobic long-chain silicone/polysiloxane as support/functional group for a model aldol reaction. The homogeneous direct aldol reaction of cyclic ketones with different aromatic aldehydes catalyzed by polysiloxane-derived primary amines has been reported with high yields, good diastereoselectivity, and up to 99% ee.
学科主题	物理化学
收录类别	SCI
资助信息	Hangzhou Normal University;the National Nature Science Foundation of China (Project No. 20572114)
语种	英语
公开日期	2012-11-09
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/1980]
专题	兰州化学物理研究所_OSSO国家重点实验室
推荐引用方式 GB/T 7714	Xu LW,Ju YD,Li L,et al. Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity[J]. Tetrahedron Letters,2008,49:7037-7041.
APA	徐利文,鞠亚东,李莉,邱化玉,蒋剑雄,&来国桥.(2008).Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity.Tetrahedron Letters,49,7037-7041.
MLA	徐利文,et al."Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity".Tetrahedron Letters 49(2008):7037-7041.