Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres

	Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres
	Ha, Wei ; Meng, Xian-Wei ; Li, Quan ; Fan, Min-Min ; Peng, Shu-Lin ; Ding, Li-Sheng ; Tian, Xuan ; Zhang, Sheng ; Li, Bang-Jing
刊名	SOFT MATTER
	2011
卷号	7 期号:3 页码:1018-1024
ISSN号	1744-683X
通讯作者	Zhang, Sheng ; Li, Bang-Jing
产权排序	1
英文摘要	This paper presents a kind of self-assembled hollow nanosphere for enzyme encapsulation. The enzyme molecules were encapsulated in hollow spheres directly in aqueous solution through the self-assembly of rod-coil Alg-g-PEG and alpha-CDs complexes. These Alg-g-PEG/alpha-CD hollow spheres showed semi-permeability which could prevent big enzyme molecules from leaving while allowing small substrates and products to pass through to maintain the enzyme activity. The permeability properties of Alg-g-PEG/alpha-CD hollow nanospheres were investigated by encapsulating different probes. The results showed that the molar mass cutoff (MMCO) of these hollow nanospheres was between 20 and 40 kDa. The encapsulation capability of Alg-g-PEG/alpha-CD hollow nanospheres was also investigated, the results indicated a maximal values for L-asparaginase encapsulation. Furthermore, the encapsulation behavior for L-asparaginase showed PEG graft density (GD) dependence.
学科主题	Chemistry; Materials Science; Physics; Polymer Science
收录类别	SCI
资助信息	National Natural Science Foundation of China (NSFC)[21074138, 51073107, 50703025]; State Key Laboratory of Polymer Materials Engineering (Sichuan University)[KF201003]
语种	英语
WOS记录号	WOS:000286615500031
公开日期	2012-11-09
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/23579]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Ha, Wei,Meng, Xian-Wei,Li, Quan,et al. Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres[J]. SOFT MATTER,2011,7(3):1018-1024.
APA	Ha, Wei.,Meng, Xian-Wei.,Li, Quan.,Fan, Min-Min.,Peng, Shu-Lin.,...&Li, Bang-Jing.(2011).Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres.SOFT MATTER,7(3),1018-1024.
MLA	Ha, Wei,et al."Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres".SOFT MATTER 7.3(2011):1018-1024.