Problems in the Microbial Production of Butanol | |
Mo Xian | |
刊名 | Journal of Industrial Microbiology & Biotechnology |
2009 | |
期号 | 36页码:1127–1138 |
关键词 | Butanol - Fermentation - Metabolic engineering - Clostridia - E. coli - Recovery techniques |
中文摘要 | With the incessant fluctuations in oil prices and increasing stress from environmental pollution, renewed attention is being paid to the microbial production of biofuels from renewable sources. As a gasoline substitute, butanol has advantages over traditional fuel ethanol in terms of energy density and hygroscopicity. A variety of cheap substrates have been successfully applied in the production of biobutanol, highlighting the commercial potential of biobutanol development. In this review, in order to better understand the process of acetone–butanol–ethanol production, traditional clostridia fermentation is discussed. Sporulation is probably induced by solvent formation, and the molecular mechanism leading to the initiation of sporulation and solventogenesis is also investigated. Different strategies are employed in the metabolic engineering of clostridia that aim to enhancing solvent production, improve selectivity for butanol production, and increase the tolerance of clostridia to solvents. However, it will be hard to make breakthroughs in the metabolic engineering of clostridia for butanol production without gaining a deeper understanding of the genetic background of clostridia and developing more efficient genetic tools for clostridia. Therefore, increasing attention has been paid to the metabolic engineering of E. coli for butanol production. The importation and expression of a non-clostridial butanol-producing pathway in E. coli is probably the most promising strategy for butanol biosynthesis. Due to the lower butanol titers in the fermentation broth, simultaneous fermentation and product removal techniques have been developed to reduce the cost of butanol recovery. Gas stripping is the best technique for butanol recovery found so far. |
学科主题 | 生物基化学品 |
语种 | 英语 |
公开日期 | 2012-11-07 |
内容类型 | 期刊论文 |
源URL | [http://ir.qibebt.ac.cn:8080/handle/337004/1104] |
专题 | 青岛生物能源与过程研究所_材料生物技术研究中心 |
推荐引用方式 GB/T 7714 | Mo Xian. Problems in the Microbial Production of Butanol[J]. Journal of Industrial Microbiology & Biotechnology,2009(36):1127–1138. |
APA | Mo Xian.(2009).Problems in the Microbial Production of Butanol.Journal of Industrial Microbiology & Biotechnology(36),1127–1138. |
MLA | Mo Xian."Problems in the Microbial Production of Butanol".Journal of Industrial Microbiology & Biotechnology .36(2009):1127–1138. |
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