Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons

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	Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
	Li, HS ; Chen, JH ; Wu, W ; Fagaly, T ; Zhou, LJ ; Yuan, WL ; Dupuis, S ; Jiang, ZH ; Nash, W ; Gick, C ; Ornitz, DM ; Wu, JY ; Rao, Y
刊名	CELL
	1999
卷号	96 期号:6 页码:807-818
关键词	GROWTH CONE GUIDANCE ODORANT RECEPTOR EXPRESSION CENTRAL-NERVOUS-SYSTEM DORSAL-ROOT GANGLIA MITRAL TUFTED CELLS EMBRYO SPINAL-CORD C-ELEGANS COMMISSURAL AXONS MOTOR AXONS FLOOR-PLATE
ISSN号	0092-8674
通讯作者	Wu, JY (reprint author), Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA,jwu@pharmdec.wustl.edu ; raoyi@thalamus.wustl.edu
英文摘要	The olfactory bulb plays a central role in olfactory information processing through its connections with both peripheral and cortical structures. Axons projecting from the olfactory bulb to the telencephalon are guided by a repulsive activity in the septum. The molecular nature of the repellent is not known. We report here the isolation of vertebrate homologs of the Drosophila slit gene and show that Slit protein binds to the transmembrane protein Roundabout (Robo). Slit is expressed in the septum whereas Robe is expressed in the olfactory bulb. Functionally, Slit acts as a chemorepellent for olfactory bulb axons. These results establish a ligand-receptor relationship between two molecules important for neural development, suggest a role for Slit in olfactory bulb axon guidance, and reveal the existence of a new family of axon guidance molecules.
学科主题	Biochemistry & Molecular Biology ; Cell Biology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2104]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Li, HS,Chen, JH,Wu, W,et al. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons[J]. CELL,1999,96(6):807-818.
APA	Li, HS.,Chen, JH.,Wu, W.,Fagaly, T.,Zhou, LJ.,...&Rao, Y.(1999).Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons.CELL,96(6),807-818.
MLA	Li, HS,et al."Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons".CELL 96.6(1999):807-818.