Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus

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	Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus
	Zhu, JJ ; Lo, FS
刊名	JOURNAL OF NEUROSCIENCE
	1999
卷号	19 期号:14 页码:5721-5730
关键词	dendrite cortex visual cortex thalamus thalamic reticular nucleus lateral posterior nucleus superior colliculus inhibitory circuits oscillation epilepsy GABA(C) receptor retina POSTERIOR-PULVINAR COMPLEX DENDRO-DENDRITIC SYNAPSES GAMMA-AMINOBUTYRIC-ACID PATCH-CLAMP RECORDINGS CENTRAL-NERVOUS-SYSTEM IN-VITRO RELAY CELLS HORIZONTAL CELLS VISUAL-CORTEX BIPOLAR CELL
ISSN号	0270-6474
通讯作者	Zhu, JJ (reprint author), Cold Spring Harbor Lab, 1 Bungtown Rd,Jones Bldg, Cold Spring Harbor, NY 11724 USA,
英文摘要	Inhibition is crucial for the thalamus to relay sensory information from the periphery to the cortex and to participate in thalamocortical oscillations. However, the properties of inhibitory synaptic events in interneurons are poorly defined because in part of the technical difficulty of obtaining stable recording from these small cells. With the whole-cell recording technique, we obtained stable recordings from local interneurons in the lateral geniculate nucleus and studied their inhibitory synaptic properties. We found that interneurons expressed three different types of GABA receptors: bicuculline-sensitive GABA(A) receptors, bicuculline-insensitive GABA(A) receptors, and GABA(B) receptors. The reversal potentials of GABA responses were estimated by polarizing the membrane potential. The GABA(A) receptor-mediated responses had a reversal potential of approximately -82 mV, consistent with mediation via Cl- channels. The reversal potential for the GABA(B) response was -97 mV, consistent with it being a K+ conductance. The roles of these GABA receptors in postsynaptic responses were also examined in interneurons. Optic tract stimulation evoked a disynaptic IPSP that was mediated by all three types of GABA receptors and depended on activation of geniculate interneurons. Stimulation of the thalamic reticular nucleus evoked an IPSP, which appeared to be mediated exclusively by bicuculline-sensitive GABA(A) receptors and depended on the activation of reticular cells. The results indicate that geniculate interneurons form a complex neuronal circuitry with thalamocortical and reticular cells via feed-forward and feedback circuits, suggesting that they play a more important role in thalamic function than thought previously.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2103]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhu, JJ,Lo, FS. Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus[J]. JOURNAL OF NEUROSCIENCE,1999,19(14):5721-5730.
APA	Zhu, JJ,&Lo, FS.(1999).Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus.JOURNAL OF NEUROSCIENCE,19(14),5721-5730.
MLA	Zhu, JJ,et al."Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus".JOURNAL OF NEUROSCIENCE 19.14(1999):5721-5730.