Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons

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	Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons
	He, LM ; Zhang, CG ; Zhou, Z ; Xu, T
刊名	NEUROSCIENCE
	2003
卷号	116 期号:2 页码:325-333
关键词	corticosterone dorsal root ganglion calcium channel protein kinase C PROTEIN-KINASE-C N-TYPE CHANNEL BLOCKERS CA2+ CHANNEL PC12 CELLS P-TYPE GLUCOCORTICOIDS FORMALIN RELEASE DEXAMETHASONE
ISSN号	0306-4522
通讯作者	Xu, T (reprint author), Huazhong Univ Sci & Technol, Inst Biophys & Biochem, Wuhan 430074, Peoples R China,
英文摘要	Corticosterone may nongenomically affect cell functions in addition to its well-characterized effects on gene expression. The purpose of this study is to examine if corticosterone has a rapid nongenomic effect on excitability of dorsal root ganglion neurons by using patch-clamp and single-cell Ca2+ microfluometry techniques. The results show that corticosterone has a dose-dependent rapid inhibitory effect on the voltage-dependent calcium currents in dorsal root ganglion neurons. Moreover, corticosterone inhibits [Ca2+](i) elevation induced by 50 mM high K+ within just 3 s. The inhibitory effects of corticosterone on the voltage-dependent calcium current and high K+-induced calcium influx diminish after adding protein kinase C inhibitor or pretreatment with pertussis toxin for 24 h. Our results demonstrate an nongenomic effect of corticosterone on the excitability of dorsal root ganglion neurons and the effect is mediated through a putative pertussis toxin-sensitive G-protein-coupled receptor and activation of protein kinase C. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2035]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	He, LM,Zhang, CG,Zhou, Z,et al. Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons[J]. NEUROSCIENCE,2003,116(2):325-333.
APA	He, LM,Zhang, CG,Zhou, Z,&Xu, T.(2003).Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons.NEUROSCIENCE,116(2),325-333.
MLA	He, LM,et al."Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons".NEUROSCIENCE 116.2(2003):325-333.