Conus peptides - A rich pharmaceutical treasure

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	Conus peptides - A rich pharmaceutical treasure
	Wang, CZ ; Chi, CW
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2004
卷号	36 期号:11 页码:713-723
关键词	Conus peptide conotoxin neuropathic disorder pharmaceutical potency K-DEPENDENT CARBOXYLASE SODIUM-CHANNELS ION-CHANNEL CALCIUM-CHANNEL VENOM PEPTIDES CONANTOKIN-G DRUG DESIGN CONOTOXIN SNAILS RECEPTOR
ISSN号	1672-9145
通讯作者	Chi, CW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China,chi@sumn.shcnc.ac.cn
英文摘要	Marine predatory cone snails (genus Conus) with over 500 species represent what is arguably the largest single genus of marine animals alive today. All Conus are venomous and utilize a complex mixture of Conus peptides to capture their preys and for other biological purposes. Each component of Conus peptides selectively targets a specific subtype of ion channels, neurotransmitter receptors or transporters. Owing to their diversity, more than 50,000 distinct active peptides are theoretically estimated in Conus venoms. These diversified toxins are generally categorized into several superfamilies and/or families based on their characteristic arrangements of cysteine residues and pharmacological actions. Some mechanisms underlying the remarkable diversity of Conus peptides have been postulated: the distinctive gene structure, gene duplication and/or allelic selection, genus speciation, and sophisticated expression pattern and post-translational modification of these peptides. Due to their highly pharmacological potency and target selectivity, Conus peptides have attracted extensive attention with their potentials to be developed as new research tools in neuroscience field and as novel medications in clinic for pain, epilepsy and other neuropathic disorders. Several instructive lessons for our drug development could be also learnt from these neuropharmacological "expertises". Conus peptides comprise a rich resource for neuropharmacologists, and most of them await to be explored.
学科主题	Biochemistry & Molecular Biology ; Biophysics
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1937]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Wang, CZ,Chi, CW. Conus peptides - A rich pharmaceutical treasure[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2004,36(11):713-723.
APA	Wang, CZ,&Chi, CW.(2004).Conus peptides - A rich pharmaceutical treasure.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,36(11),713-723.
MLA	Wang, CZ,et al."Conus peptides - A rich pharmaceutical treasure".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 36.11(2004):713-723.