A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons

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	A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons
	Hua, Y ; Chen, Z ; Hui, Z ; Wei, X ; Zhuan, Z ; Tao, X ; Jiu, PD
刊名	EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
	2005
卷号	34 期号:8 页码:1007-1016
关键词	exocytosis endocytosis Ca2+-independent but voltage-dependent secretion capacitance vesicle FROG NEUROMUSCULAR-JUNCTION SYNAPTIC VESICLE POOLS PROTEIN-KINASE-C KISS-AND-RUN NEUROTRANSMITTER RELEASE INSULIN-SECRETION CHROMAFFIN CELLS NERVE-TERMINALS CA2+ CHANNELS BETA-CELLS
ISSN号	0175-7571
通讯作者	Jiu, PD (reprint author), Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Inst Biophys & Biochem, Wuhan 430074, Peoples R China,jpding@mail.hust.edu.cn
英文摘要	In patch-clamped somata of dorsal root ganglion (DRG) neurons, two types of secretion have been proposed: Ca2(+)-dependent secretion and Ca2(+)-independent but voltage-dependent secretion (CIVDS). The Ca2+-induced and the depolarlzation-induced membrane capacitance (Cm) increases contribute 80 and 20% to the total C,, increase, respectively (Zhang and Zhou in Nat Neurosci 5:425, 2002). In order to explore the mechanism of the voltage-dependent C-m change (Delta C-m), we constructed a model with sequential states. The simulation with this model closely approximates all the experimental data. The model predicts that the majority of fusion events (approximately 80%) are so-called "kiss-and-run" events, which account for the fast recovery or the rapid retrieval feature of the signals. The remaining 20% are attributed to full fusion events, which account for a slow retrieval feature. On the basis of the model, one mechanism of the activity-dependent endocytosis has revealed a differential distribution of vesicles between the kiss-and-run and full fusion states at different stimulation frequencies. The quantitative model presented in this study may help us to understand the mechanism of the CIVDS and the tightly coupled endocytosis found in mammalian DRG neurons.
学科主题	Biophysics
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1871]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Hua, Y,Chen, Z,Hui, Z,et al. A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons[J]. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS,2005,34(8):1007-1016.
APA	Hua, Y.,Chen, Z.,Hui, Z.,Wei, X.,Zhuan, Z.,...&Jiu, PD.(2005).A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons.EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS,34(8),1007-1016.
MLA	Hua, Y,et al."A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons".EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 34.8(2005):1007-1016.