P2X(7) receptors: Properties and relevance to CNS function

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	P2X(7) receptors: Properties and relevance to CNS function
	Duan, Shumin ; Neary, Joseph T.
刊名	GLIA
	2006
卷号	54 期号:7 页码:738-746
关键词	P2X(7) neuron-glia interaction transmitter release ATP glutamate ACTIVATED PROTEIN-KINASE TUMOR-NECROSIS-FACTOR TRANSFORMED MOUSE FIBROBLASTS EXCITATORY AMINO-ACIDS FACTOR-ALPHA RELEASE NF-KAPPA-B EXTRACELLULAR ATP P2X7 RECEPTOR MICROGLIAL CELLS PURINERGIC RECEPTORS
ISSN号	0894-1491
通讯作者	Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn
英文摘要	Among seven members of P2X ionotropic receptors activated by extracellular ATP, the P2X(7) subtype is unique in that it can function as a cation channel, a nonselective pore, or even a signaling complex coupled with multiple downstream components. Several roles of P2X(7) receptors have been described in CNS cells in the past decade, including release of cytokines and transmitters, modulation of presynaptic transmitter release, and activation of multiple signaling pathways. The finding that P2X(7) pores may directly mediate efflux of cytosolic glutamate, GABA, and ATP in glial cells is particularly interesting, as it provides a novel mechanism of glial transmitter release that may play important roles not only in physiological intercellular communication but also in pathological neural injury. (c) 2006 Wiley-Liss, Inc.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1800]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Duan, Shumin,Neary, Joseph T.. P2X(7) receptors: Properties and relevance to CNS function[J]. GLIA,2006,54(7):738-746.
APA	Duan, Shumin,&Neary, Joseph T..(2006).P2X(7) receptors: Properties and relevance to CNS function.GLIA,54(7),738-746.
MLA	Duan, Shumin,et al."P2X(7) receptors: Properties and relevance to CNS function".GLIA 54.7(2006):738-746.