Myosin X regulates netrin receptors and functions in axonal path-finding

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Myosin X regulates netrin receptors and functions in axonal path-finding
	Zhu, Xiao-Juan ; Wang, Cheng-Zhong ; Dai, Peng-Gao ; Xie, Yi ; Song, Ning-Ning ; Liu, Yu ; Du, Quan-Sheng ; Mei, Lin ; Ding, Yu-Qiang ; Xiong, Wen-Cheng
刊名	NATURE CELL BIOLOGY
	2007
卷号	9 期号:2 页码:184-U79
关键词	FOCAL ADHESION KINASE GROWTH CONE GUIDANCE COLORECTAL-CANCER PLECKSTRIN HOMOLOGY NEURITE OUTGROWTH DCC PROTEIN CELLS MOTOR SRC
ISSN号	1465-7392
通讯作者	Ding, YQ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,dingyq@ion.ac.cn ; wxiong@mcg.edu
英文摘要	Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) in netrin-1 function. We find that Myo X interacts with the netrin receptor deleted in colorectal cancer (DCC) and neogenin, a DCC-related protein. Expression of Myo X redistributes DCC to the cell periphery or to the tips of neurites, whereas its silencing prevents DCC distribution in neurites. Moreover, expression of DCC, but not neogenin, stimulates Myo X-mediated formation and elongation of filopodia, suggesting that Myo X function may be differentially regulated by DCC and neogenin. The involvement of Myo X in netrin-1 function was further supported by the effects of inhibiting Myo X function in neurons. Cortical explants derived from mouse embryos expressing a motor-less Myo X exhibit reduced neurite outgrowth in response to netrin-1 and chick commissural neurons expressing the motor-less Myo X, or in which Myo X is silenced using microRNA (miRNA), show impaired axon projection in vivo. Taken together, these results identify a novel role for Myo X in regulating netrin-1 function.
学科主题	Cell Biology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1788]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhu, Xiao-Juan,Wang, Cheng-Zhong,Dai, Peng-Gao,et al. Myosin X regulates netrin receptors and functions in axonal path-finding[J]. NATURE CELL BIOLOGY,2007,9(2):184-U79.
APA	Zhu, Xiao-Juan.,Wang, Cheng-Zhong.,Dai, Peng-Gao.,Xie, Yi.,Song, Ning-Ning.,...&Xiong, Wen-Cheng.(2007).Myosin X regulates netrin receptors and functions in axonal path-finding.NATURE CELL BIOLOGY,9(2),184-U79.
MLA	Zhu, Xiao-Juan,et al."Myosin X regulates netrin receptors and functions in axonal path-finding".NATURE CELL BIOLOGY 9.2(2007):184-U79.