beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn

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	beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn
	Zhang, Bin ; Luo, Shiwen ; Dong, Xian-Ping ; Zhang, Xian ; Liu, Chunming ; Luo, Zhenge ; Xiong, Wen-Cheng ; Mei, Lin
刊名	JOURNAL OF NEUROSCIENCE
	2007
卷号	27 期号:15 页码:3968-3973
关键词	beta-catenin rapsyn interaction AChR cluster alpha-catenin NEUROMUSCULAR-JUNCTION ALPHA-CATENIN PROTEINS ACTIN AGRIN MUSK MORPHOGENESIS DICKKOPF-1 SYNAPSES FAMILY
ISSN号	0270-6474
通讯作者	Mei, L (reprint author), Med Coll Georgia, Inst Mol Med & Genet, Program Dev Neurobiol, Augusta, GA 30912 USA,lmei@mcg.edu
英文摘要	Agrin is believed to be a factor used by motoneurons to direct acetylcholine receptor (AChR) clustering at the neuromuscular junction. However, exactly how agrin mediates this effect remains unclear. Here we demonstrate that the beta-catenin interacts with rapsyn, a molecule key for AChR clustering. Agrin stimulation increases the association of beta-catenin with surface AChRs. Suppression of beta-catenin expression inhibited agrin-induced AChR clustering, suggesting a necessary role of beta-catenin in this event. The beta-catenin action did not appear to require the function of T-cell factors (TCFs), suggesting a mechanism independent of TCF-mediated transcription. In contrast, prevention of beta-catenin from interacting with beta-catenin attenuated agrin-induced AChR clustering. These results suggest that beta-catenin may serve as a link between AChRs and beta-catenin-associated cytoskeleton, revealing a novel function of beta-catenin in synaptogenesis.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1779]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhang, Bin,Luo, Shiwen,Dong, Xian-Ping,et al. beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn[J]. JOURNAL OF NEUROSCIENCE,2007,27(15):3968-3973.
APA	Zhang, Bin.,Luo, Shiwen.,Dong, Xian-Ping.,Zhang, Xian.,Liu, Chunming.,...&Mei, Lin.(2007).beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn.JOURNAL OF NEUROSCIENCE,27(15),3968-3973.
MLA	Zhang, Bin,et al."beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn".JOURNAL OF NEUROSCIENCE 27.15(2007):3968-3973.