Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition
	Zhang, Long-Hua ; Gong, Neng ; Fei, Da ; Xu, Lin ; Xu, Tian-Le
刊名	NEUROPSYCHOPHARMACOLOGY
	2008
卷号	33 期号:3 页码:701-711
关键词	glycine receptor glycine transporter hippocampus EPSP-spike coupling tonic inhibition glia TRANSPORTER SUBTYPE 1B SYNAPTIC-TRANSMISSION IN-VITRO ARACHIDONIC-ACID CROSS-INHIBITION NERVOUS-SYSTEM CA1 NEURONS SPINAL-CORD D-SERINE RAT
ISSN号	0893-133X
通讯作者	Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
英文摘要	Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their role in hippocampal function remains unclear. Since the concentration of ambient glycine is determined by the presence of powerful glycine transporter (GlyT), we blocked the reuptake of glycine in hippocampal slices to examine the role of GlyRs. Antagonists of GlyT type 1 (GlyT1) but not that of GlyT type 2 (GlyT2) induced excitatory postsynaptic potential (EPSP)-spike depression, which was reversed by the specific GlyR antagonist strychnine. Moreover, endogenously elevating the glycine concentration with the GlyT1 antagonists facilitated NMDA receptor-dependent longterm potentiation induction, and elicited a strychnine-sensitive chloride current. In addition, impairment of glial function with fluoroacetate blocked the effect of GlyT1 antagonists on the EPSP-spike curve. Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures. These results indicate an essential role of GlyTs in fine-tuning tonic activation of GlyRs and suggest a potential role of GlyR-dependent EPSP-spike depression in hippocampal network stability.
学科主题	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1741]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhang, Long-Hua,Gong, Neng,Fei, Da,et al. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition[J]. NEUROPSYCHOPHARMACOLOGY,2008,33(3):701-711.
APA	Zhang, Long-Hua,Gong, Neng,Fei, Da,Xu, Lin,&Xu, Tian-Le.(2008).Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition.NEUROPSYCHOPHARMACOLOGY,33(3),701-711.
MLA	Zhang, Long-Hua,et al."Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition".NEUROPSYCHOPHARMACOLOGY 33.3(2008):701-711.