Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation

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	Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation
	Yao, Yi-Qun ; Ding, Xia ; Jia, Yi-Chang ; Huang, Chuan-Xin ; Wang, Yi-Zheng ; Xu, Ying-Hui
刊名	CANCER LETTERS
	2008
卷号	264 期号:1 页码:127-134
关键词	beta-elemene cell cycle p38 MAPK SMOOTH-MUSCLE-CELLS PROTEIN-KINASE CYCLE ARREST IN-VITRO TRANSCRIPTIONAL REPRESSOR CANCER CELLS APOPTOSIS PATHWAY INVOLVEMENT EXPRESSION
ISSN号	0304-3835
通讯作者	Xu, YH (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn ; xuyh@dmu-1.com
英文摘要	beta-Elemene, a natural plant drug extracted from Curcuma wenyujin, has been used as an antitumor drug for different tumors, including glioblastoma. However, the mechanism of its anti-tumor effect is largely unknown. Here we report that anti-proliferation of glioblastoma cells induced by beta-elemene was dependent on p38 MAPK activation. Treatment of glioblastoma cell lines with beta-elemene, led to phosphorylation of p38 MAPK, cell-cycle arrest in G0/G1 phase and inhibition of proliferation of these cells. Inhibition of p38 MAPK reversed beta-elemene-mediated anti-proliferation effect. Furthermore, the growth of glioblastoma cell-transplanted tumors in nude mice was inhibited by intraperitoneal injection of beta-elemene. Taken together, our findings indicate that activation of p38 MAPK is critical for the anti-proliferation effect of P-elemene and that p38 MAPK might be a putative pharmacological target for glioblastoma therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
学科主题	Oncology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1724]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yao, Yi-Qun,Ding, Xia,Jia, Yi-Chang,et al. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation[J]. CANCER LETTERS,2008,264(1):127-134.
APA	Yao, Yi-Qun,Ding, Xia,Jia, Yi-Chang,Huang, Chuan-Xin,Wang, Yi-Zheng,&Xu, Ying-Hui.(2008).Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation.CANCER LETTERS,264(1),127-134.
MLA	Yao, Yi-Qun,et al."Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation".CANCER LETTERS 264.1(2008):127-134.