Synapse formation and remodeling

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	Synapse formation and remodeling
	Luo ZhenGe
刊名	SCIENCE CHINA-LIFE SCIENCES
	2010
卷号	53 期号:3 页码:315-321
关键词	synapse development neuronal activity synaptic plasticity VERTEBRATE NEUROMUSCULAR-JUNCTION AMPA RECEPTOR TRAFFICKING LONG-TERM POTENTIATION ACETYLCHOLINE-RECEPTOR PDZ-DOMAIN GERANYLGERANYLTRANSFERASE-I CHOLINE-ACETYLTRANSFERASE TARGET BINDING AGRIN RAPSYN
ISSN号	1674-7305
通讯作者	Luo, ZG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,zgluo@ion.ac.cn
英文摘要	Synapses are specialized structures that mediate information flow between neurons and target cells, and thus are the basis for neuronal system to execute various functions, including learning and memory. There are around 10(11) neurons in the human brain, with each neuron receiving thousands of synaptic inputs, either excitatory or inhibitory. A synapse is an asymmetric structure that is composed of pre-synaptic axon terminals, synaptic cleft, and postsynaptic compartments. Synapse formation involves a number of cell adhesion molecules, extracellular factors, and intracellular signaling or structural proteins. After the establishment of synaptic connections, synapses undergo structural or functional changes, known as synaptic plasticity which is believed to be regulated by neuronal activity and a variety of secreted factors. This review summarizes recent progress in the field of synapse development, with particular emphasis on the work carried out in China during the past 10 years (1999-2009).
学科主题	Life Sciences & Biomedicine - Other Topics
收录类别	SCI
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1607]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Luo ZhenGe. Synapse formation and remodeling[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(3):315-321.
APA	Luo ZhenGe.(2010).Synapse formation and remodeling.SCIENCE CHINA-LIFE SCIENCES,53(3),315-321.
MLA	Luo ZhenGe."Synapse formation and remodeling".SCIENCE CHINA-LIFE SCIENCES 53.3(2010):315-321.