Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex

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	Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex
	Shu, Yousheng
刊名	PLOS BIOLOGY
	2011
卷号	9 期号:3 页码:e1001032-e1001033
关键词	INACTIVATING K+ CURRENT ACTIVITY IN-VIVO DISYNAPTIC INHIBITION SOMATOSENSORY CORTEX PERSISTENT ACTIVITY PREFRONTAL CORTEX PYRAMIDAL NEURONS CORTICAL ACTIVITY MARTINOTTI CELLS AUDITORY-CORTEX
ISSN号	1544-9173
通讯作者	Zhu, J (reprint author), Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai Inst Biol Sci, Shanghai, Peoples R China,shu@ion.ac.cn
英文摘要	Dynamic balance of excitation and inhibition is crucial for network stability and cortical processing, but it is unclear how this balance is achieved at different membrane potentials (V(m)) of cortical neurons, as found during persistent activity or slow V(m) oscillation. Here we report that a V(m)-dependent modulation of recurrent inhibition between pyramidal cells (PCs) contributes to the excitation-inhibition balance. Whole-cell recording from paired layer-5 PCs in rat somatosensory cortical slices revealed that both the slow and the fast disynaptic IPSPs, presumably mediated by low-threshold spiking and fast spiking interneurons, respectively, were modulated by changes in presynaptic V(m). Somatic depolarization (>5 mV) of the presynaptic PC substantially increased the amplitude and shortened the onset latency of the slow disynaptic IPSPs in neighboring PCs, leading to a narrowed time window for EPSP integration. A similar increase in the amplitude of the fast disynaptic IPSPs in response to presynaptic depolarization was also observed. Further paired recording from PCs and interneurons revealed that PC depolarization increases EPSP amplitude and thus elevates interneuronal firing and inhibition of neighboring PCs, a reflection of the analog mode of excitatory synaptic transmission between PCs and interneurons. Together, these results revealed an immediate V(m)-dependent modulation of cortical inhibition, a key strategy through which the cortex dynamically maintains the balance of excitation and inhibition at different states of cortical activity.
学科主题	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
收录类别	SCI
资助信息	973 Program[2011CBA00400, 2006CB806600]; National Natural Science Foundation of China[31025012]; Shanghai Pujiang Program[07PJ14108]; Hundreds of Talents Program; Chinese Academy of Sciences[KSCX2-YW-R-102]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1550]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经网络功能研究组
推荐引用方式 GB/T 7714	Shu, Yousheng. Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex[J]. PLOS BIOLOGY,2011,9(3):e1001032-e1001033.
APA	Shu, Yousheng.(2011).Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex.PLOS BIOLOGY,9(3),e1001032-e1001033.
MLA	Shu, Yousheng."Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex".PLOS BIOLOGY 9.3(2011):e1001032-e1001033.