Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation

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	Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation
	Zhu, Lin ; Ji, Xiang-jun ; Wang, Han-dong ; Pan, Hao ; Chen, Min ; Lu, Ting-jia
刊名	BRAIN RESEARCH
	2012
卷号	1438 页码:40915
关键词	Neuron Ubiquitin Zinc Traumatic brain injury p38 TRAUMATIC BRAIN-INJURY MITOCHONDRIAL DYSFUNCTION 12-LIPOXYGENASE ACTIVATION PROTEASOME SYSTEM CORTICAL-NEURONS DEATH DEGRADATION ERYTHROPOIETIN EXPRESSION RECEPTOR
ISSN号	0006-8993
通讯作者	Wang, HD (reprint author), Nanjing Univ, Dept Neurosurg, Jinling Hosp, Sch Med, 305 E Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China,wanghandong61@126.com
英文摘要	There is increasing evidence showing that zinc plays a key role in inducing neuronal death during central nervous system injury. However, the underlying mechanisms are poorly understood. Here we assessed the effect of zinc on ubiquitin conjugation and subsequent neurodegeneration using cultured hippocampal cells. We report that cultured neurons are vulnerable to increased level of extracellular Zn2+. Zn2+-induced poly-ubiquitination in cultured neurons is in a concentration- and time-dependent manner. Furthermore our data demonstrated that Zn2+-induced ubiquitination requires p38 activation. These findings indicate that excessive zinc could impair the protein degradation pathway and may be a crucial factor mediating neuronal death following traumatic brain injury. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	Jinling Hospital of Nanjing[2008033]; Postdoctoral Foundation of Jiangsu Province, China[1002049C]; Postdoctoral Science Foundation[201150M1572]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1499]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhu, Lin,Ji, Xiang-jun,Wang, Han-dong,et al. Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation[J]. BRAIN RESEARCH,2012,1438:40915.
APA	Zhu, Lin,Ji, Xiang-jun,Wang, Han-dong,Pan, Hao,Chen, Min,&Lu, Ting-jia.(2012).Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation.BRAIN RESEARCH,1438,40915.
MLA	Zhu, Lin,et al."Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation".BRAIN RESEARCH 1438(2012):40915.