The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond
	Qiu, Zilong
刊名	NEUROSIGNALS
	2010
卷号	18 期号:2 页码:72-81
关键词	Calcium Transcription MeCP2 Copy number variations SPINOCEREBELLAR ATAXIA TYPE-1 UBIQUITIN-PROTEIN LIGASE COPY NUMBER VARIATION RETT-SYNDROME MOUSE MODEL ANGELMAN-SYNDROME TRANSCRIPTIONAL REPRESSION INTERSTITIAL DELETION SYNAPTIC-TRANSMISSION NEUROLOGICAL DISEASE
ISSN号	1424-862X
通讯作者	Qiu, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Yueyang Rd 320, Shanghai 200031, Peoples R China,zqiu@ion.ac.cn
英文摘要	During the last decade, autism spectrum disorders (ASD) have become the center of attention where several branches of modern biology unexpectedly meet, such as neural development, molecular biology, epigenetics, neurophysiology and psychiatry. This review will focus on the molecular mechanism by which calcium-dependent gene expression regulates brain development and how ASD may occur if this process is compromised. Specifically, the studies of the calcium-dependent transcriptional repressor MeCP2 gave us much insight about how abnormal development may lead to ASD. Most recently, studies about Ube3a, a critical component of the ubiquitination system enzyme, shed light on how neural activity regulates synapse function through the protein degradation pathway. Taken together, these studies suggest that ASD may be caused by the incapability of neurons to generate adaptive responses via regulating gene expression upon incoming activity. Copyright (C) 2010 S. Karger AG, Basel
学科主题	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology ; Neurosciences & Neurology
收录类别	SCI
资助信息	Hundreds of Talents Program; Chinese Academy of Sciences
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1622]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性分子基础研究组
推荐引用方式 GB/T 7714	Qiu, Zilong. The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond[J]. NEUROSIGNALS,2010,18(2):72-81.
APA	Qiu, Zilong.(2010).The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond.NEUROSIGNALS,18(2),72-81.
MLA	Qiu, Zilong."The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond".NEUROSIGNALS 18.2(2010):72-81.