Expression of fibroblast growth factors in rat dorsal root ganglion neurons and regulation after peripheral nerve injury

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	Expression of fibroblast growth factors in rat dorsal root ganglion neurons and regulation after peripheral nerve injury
	Zhang, X
刊名	NEUROREPORT
	2002
卷号	13 期号:15 页码:1903-1907
关键词	axotomy cDNA array DRG expression FGF NEUROPEPTIDE-Y SPINAL-CORD IN-VITRO REGENERATION SYSTEM BFGF FGF LOCALIZATION SURVIVAL BDNF
ISSN号	0959-4965
通讯作者	Xiao, HS (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Lab Sensory Syst, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
英文摘要	Using cDNA array, we observed the expression of eight members of the fibroblast growth factor (FGF) family, FGF 2, 5, 7,9,10,13 and 14, in rat lumbar 4 and 5 dorsal root ganglia (DRGs). Over a period of 28 days after sciatic nerve transection, the array signals for FGF 2 and 7 were significantly increased in the DRGs, while FGF 13 decreased. Using the reverse transcription polymerase chain reaction (RT-PCR), we confirmed the axotomy-induced changes in the expression of FGF 7 and 13. In situ hybridization showed that FGF 13 was expressed in 60% of DRG neurons under normal circumstance. Seven days after axotomy the number of FGF 13-positive neurons was decreased to 18%, but partially recovered to 40% after 28 days. FGF 13 immunoreactivity was also decreased. These data indicate that FGFs are important for DRG neurons under normal circumstance and after nerve injury.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2039]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组
推荐引用方式 GB/T 7714	Zhang, X. Expression of fibroblast growth factors in rat dorsal root ganglion neurons and regulation after peripheral nerve injury[J]. NEUROREPORT,2002,13(15):1903-1907.
APA	Zhang, X.(2002).Expression of fibroblast growth factors in rat dorsal root ganglion neurons and regulation after peripheral nerve injury.NEUROREPORT,13(15),1903-1907.
MLA	Zhang, X."Expression of fibroblast growth factors in rat dorsal root ganglion neurons and regulation after peripheral nerve injury".NEUROREPORT 13.15(2002):1903-1907.