Sorting of neuropeptides and neuropeptide receptors into secretory pathways | |
Zhang, Xu | |
刊名 | PROGRESS IN NEUROBIOLOGY |
2010 | |
卷号 | 90期号:2页码:276-283 |
关键词 | Neuropeptide Neuropeptide receptor Opioid receptor Substance P Sorting mechanism Secretory pathway DELTA-OPIOID RECEPTORS RAT SPINAL-CORD DORSAL-ROOT GANGLIA VENTROLATERAL PERIAQUEDUCTAL GRAY HYDROPHOBIC-HYDROPHILIC BALANCE PROTEIN-COUPLED RECEPTORS GREEN FLUORESCENT PROTEIN PH-DEPENDENT AGGREGATION PRIMARY SENSORY NEURONS CENTRAL-NERVOUS-SYSTEM |
ISSN号 | 0301-0082 |
通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn ; baolan@sibs.ac.cn |
英文摘要 | There are two major secretory pathways in neurons, the regulated pathway and the constitutive pathway. Neuropeptides and other regulated secretory proteins are known to be sorted into large dense-core vesicles of the regulated pathway in the trans-Golgi network and are secreted upon stimulus-induced increases in intracellular Ca(2+). The newly synthesized cell surface receptors are usually sorted into microvesicles of the constitutive pathway and inserted into the plasma membrane by spontaneous exocytosis. Small-diameter sensory neurons in dorsal root ganglia and pheochromocytoma cells express neuropeptides (e.g., substance P) and several neuropeptide receptors including opioid receptors. The p,opioid receptors are delivered to the cell surface through the constitutive pathway, whereas another type of opioid receptor, the delta-opioid receptor, is often found in the membrane of large dense-core vesicles and can be inserted into the plasma membrane when exocytosis occurs. Recent studies show that sequences with opposite electrical polarity within the prohormones of substance P are essential for their sorting into large dense-core vesicles. Moreover, the delta-opioid receptor is sorted into large dense-core vesicles by its interaction with protachykinin, a prohormone of substance P. These findings provide insight into the molecular mechanisms that determine the sorting and trafficking of neuropeptides and neuropeptide receptors in neurons. (C) 2009 Elsevier Ltd. All rights reserved. |
学科主题 | Neurosciences & Neurology |
收录类别 | SCI |
语种 | 英语 |
公开日期 | 2012-07-13 |
内容类型 | 期刊论文 |
源URL | [http://ir.sibs.ac.cn/handle/331001/1617] |
专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
推荐引用方式 GB/T 7714 | Zhang, Xu. Sorting of neuropeptides and neuropeptide receptors into secretory pathways[J]. PROGRESS IN NEUROBIOLOGY,2010,90(2):276-283. |
APA | Zhang, Xu.(2010).Sorting of neuropeptides and neuropeptide receptors into secretory pathways.PROGRESS IN NEUROBIOLOGY,90(2),276-283. |
MLA | Zhang, Xu."Sorting of neuropeptides and neuropeptide receptors into secretory pathways".PROGRESS IN NEUROBIOLOGY 90.2(2010):276-283. |
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