Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus | |
Weng, Zhi-Ying; Huang, Sheng-Xiong; Li, Ma-Lin; Zeng, Yue-Qin; Han, Quan-Bin; Rios, Jose Luis; Sun, Han-Dong | |
刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY |
2007-07-26 | |
卷号 | 55期号:15页码:6039-6043 |
关键词 | anti-inflammation cytotoxicity herbal tea Isodon xerophilus ent-kaurene diterpenoid |
ISSN号 | 0021-8561 |
通讯作者 | Rios, JL (reprint author), Chinese Acad Sci, Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China. riosjl@uv.es ; hdsun@mail.kib.ac.cn |
英文摘要 | Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC(50) < 11 mu M), but they had no toxicity on human T-lymphocyte (C8166). |
学科主题 | Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology |
类目[WOS] | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
研究领域[WOS] | Agriculture ; Chemistry ; Food Science & Technology |
关键词[WOS] | NF-KAPPA-B ; RABDOSIA-RUBESCENS ; DITERPENOIDS ; ACTIVATION ; CELLS |
收录类别 | SCI ; IC |
语种 | 英语 |
WOS记录号 | WOS:000248085300022 |
公开日期 | 2012-10-12 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/15406] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Coll Med, Yunnan Lab Pharmacol Nat Prod, Kunming 650031, Peoples R China 4.Univ Valencia, Dept Pharmacol, E-46100 Burjassot, Spain |
推荐引用方式 GB/T 7714 | Weng, Zhi-Ying,Huang, Sheng-Xiong,Li, Ma-Lin,et al. Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2007,55(15):6039-6043. |
APA | Weng, Zhi-Ying.,Huang, Sheng-Xiong.,Li, Ma-Lin.,Zeng, Yue-Qin.,Han, Quan-Bin.,...&Sun, Han-Dong.(2007).Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,55(15),6039-6043. |
MLA | Weng, Zhi-Ying,et al."Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 55.15(2007):6039-6043. |
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