Fine Modification of Salen Ligands-Effects on the Salen–Ti-Catalyzed Asymmetric Cyanosilylation of Aldehydes

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	Fine Modification of Salen Ligands-Effects on the Salen–Ti-Catalyzed Asymmetric Cyanosilylation of Aldehydes
	Sun W(孙伟); Wang SF(王寿峰); Xia CG(夏春谷); Sun W(孙伟)
刊名	Eur. J. Org. Chem.
	2011
页码	3407-3411
关键词	Asymmetric catalysis Dual activation Ligand design N-Oxide Cyanosilylation
ISSN号	1434-193X
通讯作者	孙伟
中文摘要	New bifunctional N-oxide salen–TiIV complexes and a pyrrolidine salen–TiIV complex in combination with achiral Noxide were developed and applied to the asymmetric addition of trimethylsilyl cyanide to aldehydes. Notably, both enantiomers of trimethylsilyl ethers of cyanohydrins could be easily prepared by modifying the catalysts employed in thisreaction, which are based on the same chiral diamine collar derived from L-tartaric acid. The products were obtained generally with moderate to good enantiomeric excesses and excellent yields by using relatively low catalyst loadings and only 1.05 equivalents of trimethylsilylcyanide (TMSCN).
学科主题	仿生与生物催化
收录类别	SCI
资助信息	the Chinese Academy of Sciences and National Natural Science Foundation of China (21073210, 20873166).
语种	英语
公开日期	2012-09-20
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/284]
专题	兰州化学物理研究所_OSSO国家重点实验室
通讯作者	Sun W(孙伟); Sun W(孙伟)
推荐引用方式 GB/T 7714	Sun W,Wang SF,Xia CG,et al. Fine Modification of Salen Ligands-Effects on the Salen–Ti-Catalyzed Asymmetric Cyanosilylation of Aldehydes[J]. Eur. J. Org. Chem.,2011:3407-3411.
APA	孙伟,王寿峰,夏春谷,&孙伟.(2011).Fine Modification of Salen Ligands-Effects on the Salen–Ti-Catalyzed Asymmetric Cyanosilylation of Aldehydes.Eur. J. Org. Chem.,3407-3411.
MLA	孙伟,et al."Fine Modification of Salen Ligands-Effects on the Salen–Ti-Catalyzed Asymmetric Cyanosilylation of Aldehydes".Eur. J. Org. Chem. (2011):3407-3411.