Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents
	Liu, Jing-Ping 1,2,3; Zhang, Hong-Bin 1; Huang, Sheng-Xiong2 ; Pu, Jian-Xin2 ; Xiao, Wei-Lie 2; Zhang, Xue-Ping 1; Xiao, Wen-Ding 1; Lei, Chun 2; Sun, Han-Dong2
刊名	JOURNAL OF HETEROCYCLIC CHEMISTRY
	2012-05-01
卷号	49 期号:3 页码:571-575
关键词	#NAME #NAME
ISSN号	0022-152X ; 0022-152X
通讯作者	Zhang, HB (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; Zhang, HB (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; zhanghb@ynu.edu.cn ; zhanghb@ynu.edu.cn ; hdsun@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
英文摘要	Laxiflorin J, isolated from the leaves of Isodon eriocalyx var. laxiflora, showed significant inhibitory activity toward T-24 cells. A series of laxiflorin J derivatives were synthesized and their in vitro activity was evaluated against BEL-7402, A-549, HT-29, HL-60, MOLT-4 tumor cell lines, with IC50 values ranging from 1.3 to 42.2 mu g mL-1.
学科主题	Chemistry, Organic ; Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	ERIOCALYX VAR. LAXIFLORA ; ENT-KAURANE DITERPENOIDS ; ISODON DITERPENOIDS ; GAS-CHROMATOGRAPHY ; WEDELIA-PALUDOSA ; KAURENOIC ACID ; KAPPA-B ; MANNER
收录类别	SCI ; IC
资助信息	Science Foundation of Yunnan Province Office of Education[2010Z084]; Natural Science Foundation of China[20832005]; Science Foundation of Yunnan Province Office of Education[2010Z084]; Natural Science Foundation of China[20832005]
语种	英语
WOS记录号	WOS:000306312700015
公开日期	2012-09-03 ; 2012-09-03
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/15097]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Yunnan Normal Univ, Dept Chem, Kunming 650092, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jing-Ping,Zhang, Hong-Bin,Huang, Sheng-Xiong,et al. Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2012,49(3):571-575.
APA	Liu, Jing-Ping.,Zhang, Hong-Bin.,Huang, Sheng-Xiong.,Pu, Jian-Xin.,Xiao, Wei-Lie.,...&Sun, Han-Dong.(2012).Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents.JOURNAL OF HETEROCYCLIC CHEMISTRY,49(3),571-575.
MLA	Liu, Jing-Ping,et al."Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents".JOURNAL OF HETEROCYCLIC CHEMISTRY 49.3(2012):571-575.