Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum
	Zhao Qing 1; Zou Cheng 2; Yu Qin 2; Zhao Sheng-Ding 1; He Hong-Ping 3; Hao Xiao-Jiang3
刊名	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
	2012-06-10
卷号	33 期号:6 页码:1220-1225
关键词	Hedychium villosum Diterpene Cytotoxic activity
ISSN号	0251-0790
通讯作者	Zhao, Q (reprint author), Yunnan Univ Tradit Chinese Med, Sch Chinese Mat Med, Kunming 650500, Peoples R China. ; qingzhaoyn2008@126.com
英文摘要	Research on active components from rhizomes of Hedychium genus has led to isolation of some diterpenes with significant cytotoxic activities against Chinese hamster V-79 cells, KB cells, K562 cells, A549 cells, etc.. Hedychium villosum Wall. is a perennial rhizomatous herb distributed in China and partially in Southeast Asia, which is used in the treatment of pain and inflammation. A new labdane-type diterpene(1), together with a known one(3), were isolated from Hedychiurn villosum. The new diterpene was named as villosumcoronarin, which partially isomerized to its epimer 1' in solution, e. g., chloroform or methanol. The gross structures of compounds 1 and 1' were elucidated on the basis of MS, ER, H-1 NMR, C-13-DEPT NMR, H-1-H-1 COSY and HMBC. The relative configuration was determined by H-1 NMR, ROESY and computational methods. Compound 1 was identified as (11S, 15R)-11-hydroxy-8(17), 12(E)-labdadien-15,16-dial 11,15-hemiacetal. The known compound 3 was oxidized by Jones reagent to get diterpene derivative 4. Bioassays revealed that compound 1 had strong cytotoxic activity against HL-60 and SMMC-7721 cells with IC50 values of 0.74 and 4.48 mu mol/L, respectively, the activities were stronger than the positive control, cis-diaminedichloroplatinum(DDP). Compound 4 also showed significant activities against HL-60 and SMMC-7721 cells with IC50 values of 3.15 and 9.57 mmol/L, respectively.
学科主题	Chemistry, Multidisciplinary
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	BASIDIOMYCETE BOREOSTEREUM-VIBRANS ; SURINAM RAIN-FOREST ; CONFIGURATION ; VIBRALACTONE ; YUNNANENSE ; CULTURES ; RHIZOMES
收录类别	SCI
语种	英语
WOS记录号	WOS:000305819100017
公开日期	2012-09-03
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/15093]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ Tradit Chinese Med, Sch Chinese Mat Med, Kunming 650500, Peoples R China 2.Kunming Med Univ, Coll Pharmaceut Sci, Kunming 650500, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Zhao Qing,Zou Cheng,Yu Qin,et al. Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2012,33(6):1220-1225.
APA	Zhao Qing,Zou Cheng,Yu Qin,Zhao Sheng-Ding,He Hong-Ping,&Hao Xiao-Jiang.(2012).Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,33(6),1220-1225.
MLA	Zhao Qing,et al."Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 33.6(2012):1220-1225.