A New Chromene Isolated from Ageratum conyzoides

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	A New Chromene Isolated from Ageratum conyzoides
	Adebayo, Abiodun Humphrey 1,2; Ji, Chang-Jiu 1; Zhang, Yu-Mei 1; He, Wen-Jun 1; Zeng, Guang-Zhi 1; Han, Hong-Jin 1; Xu, Jun-Ju 1; Akindahunsi, Afolabi Akintunde 3; Tan, Ning-Hua 1
刊名	NATURAL PRODUCT COMMUNICATIONS
	2011-09-01
卷号	6 期号:9 页码:1263-1265
关键词	Ageratum conyzoides Compositae 2 cytotoxicity 2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside
ISSN号	1934-578X
通讯作者	Adebayo, AH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
英文摘要	From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3',5'-Tri-O-methyltricetin (7), precocene 11(9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC(50) values of 12.8, 24.8, 3.5 and 7.8 mu M respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC(50) value of 61 mu M; the others showed no significant cytotoxic activity on the cell lines tested.
学科主题	Pharmacology & Pharmacy; Food Science & Technology
类目[WOS]	Chemistry, Medicinal ; Food Science & Technology
研究领域[WOS]	Pharmacology & Pharmacy ; Food Science & Technology
关键词[WOS]	DNA TOPOISOMERASE-I ; INHIBITORS ; FLAVONES
收录类别	SCI
资助信息	Chinese Academy of Sciences (CAS); Academy of Sciences for the Developing World (TWAS); National Natural Science Foundation of China[30725048]
语种	英语
WOS记录号	WOS:000294381500014
公开日期	2012-07-25
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/14479]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria 3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria
推荐引用方式 GB/T 7714	Adebayo, Abiodun Humphrey,Ji, Chang-Jiu,Zhang, Yu-Mei,et al. A New Chromene Isolated from Ageratum conyzoides[J]. NATURAL PRODUCT COMMUNICATIONS,2011,6(9):1263-1265.
APA	Adebayo, Abiodun Humphrey.,Ji, Chang-Jiu.,Zhang, Yu-Mei.,He, Wen-Jun.,Zeng, Guang-Zhi.,...&Tan, Ning-Hua.(2011).A New Chromene Isolated from Ageratum conyzoides.NATURAL PRODUCT COMMUNICATIONS,6(9),1263-1265.
MLA	Adebayo, Abiodun Humphrey,et al."A New Chromene Isolated from Ageratum conyzoides".NATURAL PRODUCT COMMUNICATIONS 6.9(2011):1263-1265.