Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats

	Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats
	Hu CX(胡春秀) ; HengWei ; Kong HW(孔宏伟) ; JildauBouwman ; TheoH.Reijmers ; ElwinR.Verheij ; ThomasHankemeier ; JanvanderGreef ; Wang M(王梅) ; Xu GW(许国旺)
	2011
会议名称	37th international symposium on high performance liquid phase separations and related techniques
会议日期	2011-10-8
会议地点	大连
页码	107-0
通讯作者	王梅 ; 许国旺
中文摘要	although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between its therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. this study systematically investigated the effects of 3- to 6-y-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes. six groups of male goto-kakizaki (gk) rats received either metformin, 3- to 6-y-old ginseng root, or no treatment. the treatments were administered twice daily for 9 weeks. a combined approach was used that involved applying liquid chromatography–mass spectrometry-based lipidomics, measuring biochemical parameters and profiling the components of ginseng roots of different ages. compared to the untreated controls, treatment with 4- and 6-y-old ginseng roots significantly improved glucose disposal, and 5-y-old ginseng treatment significantly increased high density lipoprotein cholesterol. treatment with 6-y-old ginseng significantly decreased total plasma triacylglyceride (tg) and very-low-density lipoprotein cholesterol and improved plasma glycated hemoglobin (hba1c). in addition, treatment with 4- to 6-y-old ginseng influenced plasma lipidomics in diabetic gk rats by reducing tg lipid species. metformin significantly reduced fasting blood glucose by 41% and reduced hba1c by 11%, but showed no effects on the plasma lipid parameters. the present study demonstrates that ginseng roots show growth age-dependent therapeutic effects on hyperlipidemia and hyperglycemia in diabetic gk rats. these age-dependent effects may be linked with the variation in both the ratios and concentrations of specific bioactive ginsenosides in ginseng roots of different growth ages. this study introduced novel systems biology-based approaches for linking biological activities with potential active components in herbal mixtures.
合作状况	分会口头报告
会议主办者	中国化学会色谱专业委员会
会议录	proceedings of hplc2011
会议录出版者	待补充
会议录出版地	待补充
学科主题	分析化学
内容类型	会议论文
源URL	[http://159.226.238.44/handle/321008/116060]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
推荐引用方式 GB/T 7714	Hu CX,HengWei,Kong HW,et al. Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats[C]. 见:37th international symposium on high performance liquid phase separations and related techniques. 大连. 2011-10-8.