Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats

	Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats
	Hu, Chunxiu 1,2; Wei, Heng 3,4; Kong, Hongwei 1,3; Bouwman, Jildau 4,5; Gonzalez-Covarrubias, Vanessa 2,5; van der Heijden, Rob 2; Reijmers, Theo H.2; Bao, Xu 6; Verheij, Elwin R.3,4; Hankemeier, Thomas 2,5
刊名	molecular biosystems
	2011
卷号	7 期号:11 页码:3094-3103
ISSN号	待补充
通讯作者	许国旺 ; vandergreefjan ; wangmei
产权排序	1,1
中文摘要	linking biological activity with herbal constituents by systems biology-based approaches: effects of panax ginseng in type 2 diabetic goto-kakizaki rats
英文摘要	although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between their therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. this study systematically investigated the effects of 3- to 6-year-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes. six groups of male goto-kakizaki (gk) rats received either metformin, 3- to 6-year-old ginseng roots, or no treatment. the treatments were administered twice daily for 9 weeks. a combined approach was used that involved applying liquid chromatography-mass spectrometry-based lipidomics, measuring biochemical parameters and profiling the components of ginseng roots of different ages. compared to the untreated controls, treatment with 4- and 6-year-old ginseng roots significantly improved glucose disposal, and 5-year-old ginseng treatment significantly increased high density lipoprotein cholesterol. treatment with 6-year-old ginseng significantly decreased total plasma triacylglyceride (tg) and very-low-density lipoprotein cholesterol and improved plasma glycated hemoglobin (hba1c). in addition, treatment with 4- to 6-year-old ginseng influenced plasma lipidomics in diabetic gk rats by reducing tg lipid species. metformin significantly reduced fasting blood glucose by 41% and reduced hba1c by 11%, but showed no effects on the plasma lipid parameters. the present study demonstrates that ginseng roots show growth age-dependent therapeutic effects on hyperlipidemia and hyperglycemia in diabetic gk rats. these age-dependent effects may be linked with the variation in both the ratios and concentrations of specific bioactive ginsenosides in ginseng roots of different growth ages. this study introduced novel systems biology-based approaches for linking biological activities with potential active components in herbal mixtures.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	biochemistry & molecular biology
研究领域[WOS]	biochemistry & molecular biology
关键词[WOS]	mouse model ; mellitus ; mechanisms ; therapy ; re ; metformin ; disease ; alpha ; mice ; identification
收录类别	SCI
语种	英语
WOS记录号	WOS:000295844100018
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115675]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, NL-2333 CC Leiden, Netherlands 3.Sino Dutch Ctr Prevent & Personalized Med, NL-3700 AJ Zeist, Netherlands 4.TNO, Dept Earth Environm & Life Sci, NL-3700 AJ Zeist, Netherlands 5.Leiden Univ, Netherlands Metabol Ctr, NL-2333 CC Leiden, Netherlands 6.Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, W China Sch Pharm, Chengdu 610041, Peoples R China 7.SU BioMed, NL-3700 AJ Zeist, Netherlands
推荐引用方式 GB/T 7714	Hu, Chunxiu,Wei, Heng,Kong, Hongwei,et al. Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats[J]. molecular biosystems,2011,7(11):3094-3103.
APA	Hu, Chunxiu.,Wei, Heng.,Kong, Hongwei.,Bouwman, Jildau.,Gonzalez-Covarrubias, Vanessa.,...&Wang, Mei.(2011).Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats.molecular biosystems,7(11),3094-3103.
MLA	Hu, Chunxiu,et al."Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats".molecular biosystems 7.11(2011):3094-3103.