Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway

	Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway
	Dou, Jiangli 1,2; Ma, Pan 1,2; Xiong, Chuannan 1; Tan, Chengyu 3; Du, Yuguang 1
刊名	carbohydrate polymers
	2011-08-01
卷号	86 期号:1 页码:19-24
关键词	Oligochitosan HL-60 Bax/Bcl-2 Fas/FADD p21 Galectin-9
ISSN号	0144-8617
通讯作者	杜昱光
产权排序	1,1
中文摘要	induction of apoptosis in human acute leukemia hl-60 cells by oligochitosan through extrinsic and intrinsic pathway
英文摘要	the underlying cellular and molecular mechanism about oligochitosan induced hl-60 cell apoptosis remained unknown. in the present study, we found oligochitosan treated hl-60 cells showed enhanced cleavage of poly (adp-ribose) polymerase parp and p21 expression, accompanied with g0/g1 cell cycle arrest. after treatment with oligochitosan, the pro-apoptotic molecules fas. fadd and bax were up-regulated whereas anti-apoptotic bcl-2 expression in hl-60 cells was significantly decreased. furthermore, galectin-9 mrna expression was increased in the presence of oligochitosan. we thus over-expressed galectin-9s or galectin-9l and found galectin-9 could significantly increase the oligochitosan induced apoptotic rate of hl-60 cells. collectively, our data demonstrated that oligochitosan might regulate cell cycle progression and induce hl-60 cell apoptosis through both extrinsic and intrinsic pathways. (c) 2011 elsevier ltd. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, applied ; chemistry, organic ; polymer science
研究领域[WOS]	chemistry ; polymer science
关键词[WOS]	cycle arrest ; chitosan oligosaccharides ; dna-damage ; activation ; galectin-9 ; stress
收录类别	SCI
语种	英语
WOS记录号	WOS:000293114900002
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115527]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Dalian 116023, Peoples R China 3.Dalian Ocean Univ, Coll Ocean Environm Engn, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Dou, Jiangli,Ma, Pan,Xiong, Chuannan,et al. Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway[J]. carbohydrate polymers,2011,86(1):19-24.
APA	Dou, Jiangli,Ma, Pan,Xiong, Chuannan,Tan, Chengyu,&Du, Yuguang.(2011).Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway.carbohydrate polymers,86(1),19-24.
MLA	Dou, Jiangli,et al."Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway".carbohydrate polymers 86.1(2011):19-24.