Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress

	Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress
	Qiao, Ying 1,2; Bai, Xue-Fang 1; Du, Yu-Guang 1
刊名	international immunopharmacology
	2011
卷号	11 期号:1 页码:121-127
关键词	Sepsis Lipopolysaccharide Chitosan oligosaccharides INF-alpha Lipid peroxidation
ISSN号	1567-5769
通讯作者	杜昱光
产权排序	1,1
中文摘要	chitosan oligosaccharides protect mice from lps challenge by attenuation of inflammation and oxidative stress
英文摘要	sepsis and its derivative syndromes are major causes of morbidity and mortality in the intensive care unit. recently, lots of studies have shown that the progression of sepsis is attributed to redox imbalance and overproduction of proinflammatory cytokines. in previous studies, we have reported the anti-oxidative and anti-inflammatory effects of chitosan oligosaccharides in vitro. in the light of these findings, we applied the model of sepsis to mice by lps injection to investigate whether chitosan oligosaccharides have a protective effect on lps-induced sepsis. we found that treatment by chitosan oligosaccharides not only attenuated organ dysfunction but also improved survival rate after lps injection. to further understand how it works, we examined several proinflammatory markers including neutrophil infiltration in organs and tnf-alpha and il-1 beta in serum, and found that these cytokines were significantly reduced by chitosan oligosaccharide treatment. in addition to this, anti-oxidants including glutathione (gsh) and catalase (cat) levels were depleted and malondialdehyde (mda) levels were increased in lps-induced sepsis, while chitosan oligosaccharides smoothed out the redox imbalance. furthermore, we also assessed c-jun nh(2)-terminal kinase and p38 mitogen-activated protein kinase signal activation by lps-stimulation, and found both of them were attenuated by chitosan oligosaccharide treatment. collectively, our data demonstrated that chitosan oligosaccharides can protect mice from the lps challenge by virtue of anti-inflammatory effects as well as anti-oxidation properties, which might offer beneficial effects for patients with sepsis. (c) 2010 elsevier b.v. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	immunology ; pharmacology & pharmacy
研究领域[WOS]	immunology ; pharmacology & pharmacy
关键词[WOS]	septic shock ; in-vitro ; endotoxin-shock ; hyaluronic-acid ; antioxidant ; sepsis ; chitooligosaccharides ; model ; kinase ; cells
收录类别	SCI
语种	英语
WOS记录号	WOS:000287065300016
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115513]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dept Biotechnol, Dalian 116023, Liaoning, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Ying,Bai, Xue-Fang,Du, Yu-Guang. Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress[J]. international immunopharmacology,2011,11(1):121-127.
APA	Qiao, Ying,Bai, Xue-Fang,&Du, Yu-Guang.(2011).Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress.international immunopharmacology,11(1),121-127.
MLA	Qiao, Ying,et al."Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress".international immunopharmacology 11.1(2011):121-127.