Analysis of cephalosporins by hydrophilic interaction chromatography

	Analysis of cephalosporins by hydrophilic interaction chromatography
	Liu, Qiaoxia 1; Xu, Lingyan 1; Ke, Yanxiong 1; Jin, Yu 1; Zhang, Feifang 1; Liang, Xinmiao 1,2
刊名	journal of pharmaceutical and biomedical analysis
	2011-02-20
卷号	54 期号:3 页码:623-628
关键词	Cephalosporins Hydrophilic interaction chromatography The Click beta-CD column Reversed-phase high performance liquid chromatography
ISSN号	待补充
通讯作者	金郁 ; 章飞芳
产权排序	2,6
中文摘要	analysis of cephalosporins by hydrophilic interaction chromatography
英文摘要	a simple hydrophilic interaction chromatography (hilic) method was developed to analyze seven cephalosporins. these seven cephalosporins could be separated well on the click beta-cd column and atlantis hilic silica column. the effects of buffer concentration and ph on the retention under hilic mode were studied. except cefepime hydrochloride (4), the retention of other six cephalosporins increased with increasing buffer concentration, while decreased with increasing ph. different separation selectivities could be observed on the click beta-cd column and atlantis hilic silica column, and changing ph also resulted in the changing of separation selectivity. the separations of cephalosporins by hilic and reversed-phase high performance liquid chromatography (rp-hplc) were compared, and the two separation modes had good orthogonality. in addition, cefotaxime sodium (1) and its degradation were separated well on the click beta-cd column, which indicated that the click beta-cd column by hilic can be used for studying the stability of cephalosporins. (c) 2010 published by elsevier b.v.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences ; life sciences & biomedicine
类目[WOS]	chemistry, analytical ; pharmacology & pharmacy
研究领域[WOS]	chemistry ; pharmacology & pharmacy
关键词[WOS]	performance liquid-chromatography ; electrospray mass-spectrometry ; reversed-phase ; ion-exchange ; polar compounds ; drug discovery ; separation ; urine ; mode
收录类别	SCI
语种	英语
WOS记录号	WOS:000284814300033
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115356]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiaoxia,Xu, Lingyan,Ke, Yanxiong,et al. Analysis of cephalosporins by hydrophilic interaction chromatography[J]. journal of pharmaceutical and biomedical analysis,2011,54(3):623-628.
APA	Liu, Qiaoxia,Xu, Lingyan,Ke, Yanxiong,Jin, Yu,Zhang, Feifang,&Liang, Xinmiao.(2011).Analysis of cephalosporins by hydrophilic interaction chromatography.journal of pharmaceutical and biomedical analysis,54(3),623-628.
MLA	Liu, Qiaoxia,et al."Analysis of cephalosporins by hydrophilic interaction chromatography".journal of pharmaceutical and biomedical analysis 54.3(2011):623-628.